This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
PICALM Antibodies
AND PICALM ELISA kits, PICALM Proteins
Many biological assays use antibodies to detect PICALM, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PICALM in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PICALM antibodies...
Designing an IHC experiment for PICALM? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the PICALM IHC GuidePICALM Infographic by Boster Bio
All PICALM Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A02053-1
100 μg/vial
Cat # A02053-1
100 μg/vial
PICALM Overview
Facts about Phosphatidylinositol-binding clathrin assembly protein.
Phosphatidylinositol-binding clathrin assembly protein (PICALM)
Assembly protein recruitment clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly. May be required to determine the amount of membrane to be recycled, possibly by regulating the size of the clathrin cage.
Involved in AP2-dependent clathrin-mediated endocytosis at the neuromuscular junction. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PICALM |
| Uniprot: | Q13492 |
| Entrez: | 8301 |
Family
| Belongs to: |
|---|
| PICALM/SNAP91 family |
Alternative Names
CALMclathrin assembly lymphoid-myeloid leukemia; Clathrin assembly lymphoid myeloid leukemia protein; CLTHphosphatidylinositol-binding clathrin assembly protein; LAP; phosphatidylinositol binding clathrin assembly protein
Molecular Weight
Mass (kDA):
70.755 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 11q14.2 |
| Sequence: | 11; NC_000011.10 (85957175..86069860, complement) |
Tissue Specificity
Expressed in all tissues examined.
Subcellular Localizations
Cell membrane. Membrane, clathrin-coated pit. Golgi apparatus. Cytoplasmic vesicle, clathrin-coated vesicle. Nucleus. Colocalized with clathrin in the Golgi area (PubMed:10436022). Interaction with PIMREG may target PICALM to the nucleus in some cells (PubMed:16491119).
Diseases
- Alzheimer's Disease
- Leukemia
- Myeloid Leukemia
- Dementia
- Leukemia, Myelocytic, Acute
- Impaired Cognition
- Neurodegenerative Disorders
- Acute Lymphocytic Leukemia
- Lymphoma
- Chromosomal Translocation
- Leukemogenesis
- Nerve Degeneration
Interacting Proteins
- FHL2
Pathways
- Endocytosis
- Pathogenesis
- Clathrin-mediated Endocytosis
- Aging
- Transport
- Localization
- Cognition
- Translation
- Secretory Pathway
- Intracellular Transport
- Nuclear Export
- Exocytosis
- Methylation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PICALM
bosterbio.com/bosterbio-gene-info-cards/PICALM
References
PMID: 8643484 by Dreyling M.H., et al. The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.
PMID: 9737689 by Silliman C.C., et al. Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10- CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14- q21) suggests a potential role for truncated AF10 polypeptides.