This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
, No Gclids
PIN4 Antibodies
AND PIN4 ELISA kits, PIN4 Proteins
Many biological assays use antibodies to detect PIN4, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PIN4 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PIN4 antibodies...
Previous: CBLIF
Next: PIP
PIN4 Infographic by Boster Bio
All PIN4 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
IHC, WB
$523
Cat # M05181
100 µl
Cat # M05181
100 µl
Human, Mouse, Rat
IF, IHC, ICC, WB
$370
Cat # M05181-1
100 μl/vial
Cat # M05181-1
100 μl/vial
PIN4 Overview
Facts about Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4.
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (PIN4)
Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA.
.
Gene Information
| Human | |
|---|---|
| Gene Name: | PIN4 |
| Uniprot: | Q9Y237 |
| Entrez: | 5303 |
Family
| Belongs to: |
|---|
| PpiC/parvulin rotamase family |
Alternative Names
4 (parvulin); MGC138486; Parvulin-17; protein (peptidylprolyl cis/trans isomerase) NIMA-interacting, 4 (parvulin)
Molecular Weight
Mass (kDA):
13.81 kDA
Genomic Context
| Human | |
|---|---|
| Location: | Xq13.1 |
| Sequence: | X; NC_000023.11 (72181676..72263964) |
Tissue Specificity
Isoform 2 is much more stable than isoform 1 (at protein level). Ubiquitous. Isoform 1 and isoform 2 are expressed in kidney, liver, blood vessel, brain, mammary gland, skeletal muscle, small intestine and submandibularis. Isoform 1 transcripts are much more abundant than isoform 2 in each tissue analyzed.
Subcellular Localizations
[Isoform 1]: Nucleus, nucleolus. Cytoplasm, cytoskeleton, spindle. Cytoplasm. Colocalizes in the nucleolus during interphase and on the spindle apparatus during mitosis with NPM1.; [Isoform 2]: Mitochondrion. Mitochondrion matrix. Imported in a time- and membrane potential-dependent manner to the mitochondrial matrix, but without concomitant processing of the protein. Directed to mitochondria by a novel N-terminal domain that functions as non-cleavable mitochondrial targeting peptide.
Diseases
- Malignant Neoplasms
- Monosomy
- Liver Diseases
- Prostatic Atypical Adenomatous Hyperplasia
- Neoplasms
- Atypical Adenomatous Hyperplasia
- Plant Diseases
- Trematode Infections
- Precancerous Conditions
- Biliary Cirrhosis
- Adenocarcinoma
- Malignant Neoplasm Of Prostate
Interacting Proteins
- CEP72
- FAM9B
- FATE1
- PNMA1
- ZBTB9
Pathways
- Auxin Efflux
- Transport
- Auxin Transport
- Localization
- Embryo Development
- Germination
- Stem Cell Maintenance
- Auxin Homeostasis
- Adventitious Root Development
- Hypersensitivity
- Cell Fate Determination
- Regulation Of Gene Expression
- Cell Division
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PIN4
bosterbio.com/bosterbio-gene-info-cards/PIN4
References
PMID: 10364457 by Rulten S.L., et al. Identification of eukaryotic parvulin homologues: a new subfamily of peptidylprolyl cis-trans isomerases.
PMID: 10100858 by Uchida T., et al. Identification and characterization of a 14 kDa human protein as a novel parvulin-like peptidyl prolyl cis/trans isomerase.