PLCL1 Antibodies

AND PLCL1 ELISA kits, PLCL1 Proteins

Many biological assays use antibodies to detect PLCL1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PLCL1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PLCL1 antibodies...

We validate the specificity of these antibodies to PLCL1 by testing them on tissues known to express PLCL1 positively and negatively. Browse below to find the PLCL1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Previous: CBLIF Next: PLCG1

PLCL1 Infographic by Boster Bio

All PLCL1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

PLCL1 (NM_006226) Human Over-expression Lysate

Human

$960
Cat # LS005334
20 µg, 100 µg

PLCL1 Overview

Facts about Inactive phospholipase C-like protein 1.

PLCL1 3D structure. Source: alphafold

Inactive phospholipase C-like protein 1 (PLCL1)

Involved in an inositol phospholipid-based intracellular signaling cascade. Shows no PLC action to phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol.

Component in the phospho-dependent endocytosis process of GABA A receptor (By similarity). Regulates the turnover of receptors and thus contributes to the maintenance of GABA-mediated synaptic inhibition.

Gene Information

Human
Gene Name:	PLCL1
Uniprot:	Q15111
Entrez:	5334

Family

Belongs to:

No superfamily

Alternative Names

but catalytically inactive protein; inactive phospholipase C-like protein 1; MGC126580; MGC138190; phospholipase C, epsilon; phospholipase C-deleted in lung carcinoma; phospholipase C-like 1; phospholipase C-related but catalytically inactive protein; PLCE; PLCL; PLC-L1; PRIP

Molecular Weight

Mass (kDA):
122.728 kDA

Genomic Context


Human

Location:	2q33.1
Sequence:	2; NC_000002.12 (197804593..198149873)

Tissue Specificity

Expressed in a variety of fetal and adult organs including brain, lung and kidney. Its expression was greatly reduced in small and non-small cell lung carcinoma. Isoform 1 is predominantly expressed in brain.

Subcellular Localizations

Cytoplasm.

Diseases

Fracture
Osteoporosis
Hereditary Diseases
Spinal Fractures
Hip Fractures
Osteoporosis, Postmenopausal
Malignant Neoplasms
Pituitary Diseases
Inflammation

Bone Diseases
Dysequilibrium Syndrome
Metabolic Bone Disorder

Pathways

Pathogenesis
Gonadotropin Secretion
Bone Remodeling
Secretion

PTMs

Phosphoprotein

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PLCL1

References

PMID: 7633416 by Kohno T., et al. Identification of a novel phospholipase C family gene at chromosome 2q33 that is homozygously deleted in human small cell lung carcinoma.

PMID: 11278544 by Yoshimura K., et al. Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1alpha.