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Prepronociceptin Antibodies
AND PNOC ELISA kits, Prepronociceptin Proteins
Many biological assays use antibodies to detect Prepronociceptin, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prepronociceptin in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prepronociceptin antibodies...
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PNOC Infographic by Boster Bio
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PNOC Overview
Facts about Prepronociceptin.
Prepronociceptin (PNOC)
Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may work as a transmitter in the brain by modulating nociceptive and locomotor behavior.
May be involved in neuronal differentiation and development. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PNOC |
| Uniprot: | Q13519 |
| Entrez: | 5368 |
Family
| Belongs to: |
|---|
| opioid neuropeptide precursor family |
Alternative Names
nociceptin; nocistatin; OFQ; P; PPNOC; prepronociceptin; propronociceptin
Molecular Weight
Mass (kDA):
20.295 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 8p21.1 |
| Sequence: | 8; NC_000008.11 (28316979..28343355) |
Tissue Specificity
Predominantly expressed in the brain and spinal cord. Also expressed and secreted by peripheral blood neutrophils following degranulation.
Subcellular Localizations
Secreted.
Diseases
- Inhalation Exposure
- Neoplasms
- Pain
- Multiple Acyl Coenzyme A Dehydrogenase Deficiency
- Disease Of Adrenal Medulla
- Mood Disorders
- Substance-related Disorders
- Malignant Neoplasm Of Breast
- Neurodegenerative Disorders
- Inflammatory Response
- Carcinoma
- Malignant Neoplasms
Pathways
- Neurogenesis
- Autolysis
- Pathogenesis
- Inflammatory Response
PTMs
- Cleavage on pair of basic residues
Research Areas
- Neuroscience
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PNOC
bosterbio.com/bosterbio-gene-info-cards/PNOC
References
PMID: 8710928 by Mollereau C., et al. Structure, tissue distribution, and chromosomal localization of the prepronociceptin gene.
PMID: 8710930 by Nothacker H.-P., et al. Primary structure and tissue distribution of the orphanin FQ precursor.