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Polr1a Antibodies
AND Polr1a ELISA kits, Polr1a Proteins
Many biological assays use antibodies to detect Polr1a, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Polr1a in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Polr1a antibodies...
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Polr1a Overview
Facts about DNA-directed RNA polymerase I subunit RPA1.
DNA-directed RNA polymerase I subunit RPA1 (Polr1a)
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic core component of RNA polymerase I which synthesizes ribosomal RNA precursors.
Forms the polymerase active center along with the second largest subunit. A single stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol I.
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Polr1a |
| Uniprot: | O35134 |
| Entrez: | 20019 |
Family
| Belongs to: |
|---|
| RNA polymerase beta' chain family |
Alternative Names
DNA-directed RNA polymerase I subunit RPA1; A190; polymerase (RNA) I polypeptide A, 194kDa; RPA1; RPA194; RPO14; RPO1-4
Molecular Weight
Mass (kDA):
194.11 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 6 C1|6 32.21 cM |
| Sequence: | 6; |
Diseases
- Malignant Neoplasms
- Neoplasms
Pathways
- Ribosome Biogenesis
- Rrna Transcription
- Methylation
- Cell Proliferation
- Cell Cycle
- Dna Methylation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Polr1a
bosterbio.com/bosterbio-gene-info-cards/Polr1a
References
PMID: 9236775 by Seither P., et al. Molecular cloning and characterization of the cDNA encoding the largest subunit of mouse RNA polymerase I.
PMID: 16514417 by Percipalle P., et al. The chromatin remodelling complex WSTF-SNF2h interacts with nuclear myosin 1 and has a role in RNA polymerase I transcription.