DNA-directed RNA polymerase II subunit RPB2 (POLR2B)

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and lots of functional non-coding RNAs.

Proposed to donate to the polymerase catalytic activity and forms the polymerase active center with the largest subunit. Pol II is the central part of the basal RNA polymerase II transcription machinery.