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POU4F1 Antibodies
AND POU4F1 ELISA kits, POU4F1 Proteins
Many biological assays use antibodies to detect POU4F1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POU4F1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POU4F1 antibodies...
Designing a Western blot for POU4F1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the POU4F1 Western Blot GuidePOU4F1 Infographic by Boster Bio
All POU4F1 Products
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Specificity
Applications
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POU4F1 Overview
Facts about POU domain, class 4, transcription factor 1.
POU domain, class 4, transcription factor 1 (POU4F1)
Multifunctional transcription factor with different regions mediating its different consequences. Acts by binding (via its C-terminal domain) to sequences about the consensus octamer motif 5'-ATGCAAAT-3' in the regulatory regions of its target genes.
Regulates the expression of certain genes involved in differentiation and survival within a subset of neuronal lineages. It has been shown that activation of some of these genes requires its N-terminal domain, maybe through a neuronal-specific cofactor.
Gene Information
| Human | |
|---|---|
| Gene Name: | POU4F1 |
| Uniprot: | Q01851 |
| Entrez: | 5457 |
Family
| Belongs to: |
|---|
| POU transcription factor family |
Alternative Names
Brain-3A; Brain-specific homeobox/POU domain protein 3A; brn-3A; BRN3Abrain-3A; FLJ13449; Homeobox/POU domain protein RDC-1; Oct-T1; POU class 4 homeobox 1; POU domain class 4, transcription factor 1; POU domain, class 4, transcription factor 1; RDC1; RDC-1
Molecular Weight
Mass (kDA):
42.697 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 13q31.1 |
| Sequence: | 13; NC_000013.11 (78598362..78603552, complement) |
Tissue Specificity
Expressed in the brain and the retina. Present in the developing brain, spinal cord and eye.
Subcellular Localizations
Nucleus. Cytoplasm.
Diseases
- Nervousness
- Neoplasms
- Malignant Neoplasms
- Uterine Cervical Neoplasm
- Neuroblastoma
- Crest Syndrome
- Malignant Tumor Of Cervix
- Sarcoma
- Glaucoma
- Cervical Intraepithelial Neoplasia
- Papilloma
- Ewings Sarcoma-primitive Neuroectodermal Tumor (pnet)
Pathways
- Cell Death
- Neurogenesis
- Cell Development
- Cell Differentiation
- Programmed Cell Death
- Cell Cycle
- Cell Adhesion
- Regulation Of Gene Expression
- Localization
- Aging
- Dosage Compensation
- Cell Cycle Arrest
- Translation
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POU4F1
bosterbio.com/bosterbio-gene-info-cards/POU4F1
References
PMID: 1357630 by Collum R.G., et al. A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system.
PMID: 8234287 by Bhargava A.K., et al. Differential expression of four members of the POU family of proteins in activated and phorbol 12-myristate 13-acetate-treated Jurkat T cells.
2 Publications of Boster POU4F1 Antibodies & ELISA Kits
- PubMed ID: 10.1007/s12640-016-9624-6, The Toxic Effect of ALLN on Primary Rat Retinal Neurons
- PubMed ID: 24884644, Calpain: a molecule to induce AIF-mediated necroptosis in RGC-5 following elevat...
*More publications can be found for each product on its corresponding product page