POU4F2 Antibodies

AND POU4F2 ELISA kits, POU4F2 Proteins

Many biological assays use antibodies to detect POU4F2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POU4F2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POU4F2 antibodies...

We validate the specificity of these antibodies to POU4F2 by testing them on tissues known to express POU4F2 positively and negatively. Browse below to find the POU4F2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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POU4F2 Infographic by Boster Bio

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POU4F2 (NM_004575) Human Over-expression Lysate

Human

$628
Cat # LS005458
20 µg, 100 µg

POU4F2 Overview

Facts about POU domain, class 4, transcription factor 2.

POU4F2 3D structure. Source: alphafold

POU domain, class 4, transcription factor 2 (POU4F2)

Functions either as activator or repressor regulating the rate of target gene transcription through RNA polymerase II receptor at a promoter-dependent manner (PubMed:19266028, PubMed:23805044). Binds to the consensus octamer motif 5'-AT[A/T]A[T/A]T[A/T]A-3' of promoter of target genes.

Plays a fundamental role in the gene regulatory system necessary for retinal ganglion cell (RGC) differentiation. Binds to an octamer site to form a ternary complex with ISL1; cooperates favorably with ISL1 and ISL2 to potentiate transcriptional activation of RGC target genes being included in RGC fate commitment in the developing retina and RGC axon formation and pathfinding.

Gene Information

Human
Gene Name:	POU4F2
Uniprot:	Q12837
Entrez:	5458

Family

Belongs to:

POU transcription factor family

Alternative Names

POU domain, class 4, transcription factor 2; BRN3.2; BRN3B; Brn-3b; POU class 4 homeobox 2

Molecular Weight

Mass (kDA):
43.087 kDA

Genomic Context


Human

Location:	4q31.22
Sequence:	4; NC_000004.12 (146638893..146642474)

Tissue Specificity

Expressed in the brain (PubMed:7691107). Expressed in the ganglion cell layer of the retina (PubMed:7691107).

Subcellular Localizations

Nucleus. Nucleus speckle. Cytoplasm.

Diseases

Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Breast
Mammary Neoplasms
Neuroblastoma
Nervousness
Cell Invasion
Cell Transformation, Neoplastic
Nerve Degeneration
Disorder Of The Optic Nerve
Microphthalmos
Neoplasm Invasiveness
Malignant Neoplasm Of Urinary Bladder

Adenocarcinoma
Glaucoma
Blind Vision
Nephroblastoma
Growth Arrest
Papilloma
Uterine Cervical Neoplasm

Interacting Proteins

GRN
KPRP
KRTAP10-9
KRTAP12-1
KRTAP12-3

KRTAP4-12
KRTAP9-2
KRTAP9-8

Pathways

Cell Cycle
Neurogenesis
Cell Development
Cell Differentiation
Cell Growth
Methylation
Regulation Of Gene Expression
System Development
Cell Proliferation
Localization
Drug Resistance
Cell Death
Cell Migration

Reflex
Cell Cycle Arrest
Cell Fate Specification
Reverse Transcription
Translation
Axon Guidance
Osteoclast Maturation

PTMs

Methylation

Phosphorylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POU4F2

References

PMID: 7691107 by Xiang M., et al. Brn-3b: a POU domain gene expressed in a subset of retinal ganglion cells.

PMID: 8332509 by Ring C.J.A., et al. The human Brn-3b POU transcription factor shows only limited homology to the Brn-3a/RDC-1 factor outside the conserved POU domain.