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Protein phosphatase 1B Antibodies
AND PPM1B ELISA kits, Protein phosphatase 1B Proteins
Many biological assays use antibodies to detect Protein phosphatase 1B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Protein phosphatase 1B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Protein phosphatase 1B antibodies...
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PPM1B Infographic by Boster Bio
All PPM1B Products
Product
Figures
Specificity
Applications
Price
Dog, Human, Monkey, Mouse, Rat
Flow Cytometry, WB
$523
Cat # M05731
100 µl
Cat # M05731
100 µl
Human, Mouse, Rat
Flow Cytometry, IF, WB
$523
Cat # M05731-1
100 µl
Cat # M05731-1
100 µl
Human, Mouse, Rat
IHC, WB
$523
Cat # M05731-2
100 µl
Cat # M05731-2
100 µl
PPM1B Overview
Facts about Protein phosphatase 1B.
Protein phosphatase 1B (PPM1B)
Enzyme with a broad specificity. Dephosphorylates CDK2 and CDK6 in vitro.
Dephosphorylates PRKAA1 and PRKAA2. Inhibits TBK1-mediated antiviral signaling by dephosphorylating it 'Ser- 172'.
Gene Information
| Human | |
|---|---|
| Gene Name: | PPM1B |
| Uniprot: | O75688 |
| Entrez: | 5495 |
Family
| Belongs to: |
|---|
| PP2C family |
Alternative Names
EC 3.1.3.16; MGC21657; PP2C beta; Pp2c2; PP2CB; PP2C-beta; PP2C-beta-X; PP2CBmagnesium-dependent, beta isoform; PPM1B; protein phosphatase 1B; Protein phosphatase 2C isoform beta; protein phosphatase 2C-like protein; protein phosphatase, Mg2+/Mn2+ dependent, 1B
Molecular Weight
Mass (kDA):
52.643 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2p21 |
| Sequence: | 2; NC_000002.12 (44168803..44247330) |
Tissue Specificity
Highly expressed in heart and skeletal muscle.
Subcellular Localizations
Cytoplasm, cytosol. Membrane; Lipid-anchor. Weakly associates at the membrane and N-myristoylation mediates the membrane localization.
Diseases
- Cystinuria
- Muscle Hypotonia
- Congenital Anomaly Of Face
- Cytochrome-c Oxidase Deficiency
- Somatotropin Deficiency
- Moderate Mental Retardation
- Isolated Cystinuria
- Endometrial Polyp
- Hypokinesia
- Carcinogenesis
- Malignant Neoplasms
Interacting Proteins
- ARRB1
- ARRB2
- ISG15
Pathways
- Translation
- Cell Death
- Cell Cycle
- Axon Guidance
- Dna Repair
- Energy Homeostasis
- Muscle Atrophy
PTMs
- Phosphorylation
Research Areas
- Stem Cell Markers
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPM1B
bosterbio.com/bosterbio-gene-info-cards/PPM1B
References
PMID: 9684878 by Marely A.E., et al. The cloning expression and tissue distribution of human PP2Cbeta.
PMID: 10934208 by Cheng A., et al. Dephosphorylation of human cyclin-dependent kinases by protein phosphatase type 2Calpha and beta2 isoforms.