PPP2CA Antibodies

Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA)

PP2A is the major phosphatase for microtubule-associated proteins (MAPs). PP2A can modulate the activity of phosphorylase B kinase casein kinase 2, mitogen-stimulated S6 kinase, and MAP-2 kinase.

Cooperates with SGO2 to protect centromeric cohesin from separase-mediated cleavage in oocytes especially during meiosis I (By similarity). Can dephosphorylate SV40 large T antigen and p53/TP53.

Gene Information

Human
Gene Name:	PPP2CA
Uniprot:	P67775
Entrez:	5515

Family

Belongs to:
PPP phosphatase family

Alternative Names

EC 3.1.3.16; PP2A; PP2A-alpha; PP2Ac; PP2CA; PP2Calpha; PPP2CA; protein phosphatase 2 (formerly 2A), catalytic subunit, alpha isoform; protein phosphatase 2, catalytic subunit, alpha isozyme; protein phosphatase 2A catalytic subunit, alpha isoform; Replication protein C; RP-C; serine/threonine protein phosphatase 2A, catalytic subunit, alpha isoform; serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

Molecular Weight

Mass (kDA):
35.594 kDA

Genomic Context

Human
Location:	5q31.1
Sequence:	5; NC_000005.10 (134194332..134226073, complement)

Subcellular Localizations

Cytoplasm. Nucleus. Chromosome, centromere. Cytoplasm, cytoskeleton, spindle pole. In prometaphase cells, but not in anaphase cells, localizes at centromeres. During mitosis, also found at spindle poles. Centromeric localization requires the presence of SGO2 (By similarity).

Diseases

• Malignant Neoplasms
• Neoplasms
• Alzheimer's Disease
• Cell Transformation, Neoplastic
• Neurofibrillary Tangles
• Leukemia
• Tissue Adhesions
• Leukemia, Myelocytic, Acute
• Malignant Neoplasm Of Prostate
• Retinoblastoma
• Malignant Neoplasm Of Breast
• Malignant Tumor Of Colon
• Myeloid Leukemia

• Lupus Erythematosus, Systemic
• Mammary Neoplasms
• Colonic Neoplasms
• Melanoma
• Hyperhomocysteinemia
• Immunologic Deficiency Syndromes
• Adenocarcinoma

Interacting Proteins

• AKT1
• ANP32A
• EIF4E
• IER3
• IGBP1

• Igbp1
• IKBKB
• IKBKG
• KISS1R
• Nxn

• PPME1
• PPP2R1A
• PPP2R1B
• PPP2R2C
• PPP2R5A

• PPP2R5B
• PPP2R5C
• RAF1
• RBL1
• RBL2

• RELA
• SGO1
• STRIP1
• STRN
• TIPRL

• TRIP13

Pathways

• Localization
• Cell Cycle
• Cell Proliferation
• Hyperphosphorylation
• Cell Death
• Cell Growth
• Translation
• Mitosis
• Pathogenesis
• Nuclear Export
• Protein Phosphorylation
• Nuclear Import
• Methylation

• Senescence
• Dna Replication
• Immune Response
• Cell Cycle Arrest
• Cytokinesis
• Cell Differentiation
• Interphase

PTMs

• Phosphorylation
• Dephosphorylation
• Cleavage

• Methylation
• Deacetylation
• Ribosylation

• Ubiquitination

Research Areas

• Breast Cancer
• Cancer
• Cell Cycle and Replication
• Checkpoint signaling
• DNA Double Strand Break Repair

• DNA Repair
• Neuronal Cell Markers
• Neurotransmission
• Phospho-Specific
• Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPP2CA

Boster Bio Anti-PP2A Alpha - Best Uses Of The PPP2CA Marker

As a scientist, you should know how to get the most from your Boster Bio Anti-PP2A-alpha. A Boster Bio optimization guide will assist you in making better decisions and enhance your results. There is a chance you will come across errors of some sort in your research. You can eliminate many potential errors by using proper controls and methods. Troubleshooting guides can be useful in identifying the cause of errors and eliminating them.

Boster Bio Anti-PP2A-alpha

Boster Bio produces ELISA kits and research antibodies for the detection of biomarkers that are used in the fields of cancer, neurosciences, development biology, and inflammation. The antibodies have been tested against more than 250 tissue samples and possess high affinity, which allows them to be employed in both qualitative and quantitative applications. The products of the company's immunological lab are available through its website tebu-bio.

PP2A is a major phosphatase of MAPs. It regulates the activities of the phosphorylase B-kinase and the casein kinase. It also collaborates with SGO2 to protect the centromeric cohesin, activates RAF1 and plays a role in the dephosphorylation of WEE1. Antibodies against PP2A hinder cell growth, stimulate the G2/M checkpoint and regulate gene expression in various tissues.

The anti-PP2A-alpha PPP2CA antibody is available from Boster Bio. The product is available in several formats, including IHC and WB. Boster Bio Anti PP2A-alpha PP2CA Antibody reacts to human mouse, human, and PP2A. It is also suitable for immunohistochemistry as well as Western blot.