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PPP2R5C Antibodies
AND PPP2R5C ELISA kits, PPP2R5C Proteins
Many biological assays use antibodies to detect PPP2R5C, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PPP2R5C in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PPP2R5C antibodies...
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PPP2R5C Infographic by Boster Bio
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PPP2R5C Overview
Facts about Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform.
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform (PPP2R5C)
The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The PP2A-PPP2R5C holoenzyme may specifically dephosphorylate and activate TP53 and play a role in DNA damage- induced inhibition of cell proliferation.
PP2A-PPP2R5C may also regulate the ERK signaling pathway through ERK dephosphorylation. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PPP2R5C |
| Uniprot: | Q13362 |
| Entrez: | 5527 |
Family
| Belongs to: |
|---|
| phosphatase 2A regulatory subunit B56 family |
Alternative Names
B' alpha regulatory subunit; B56G; KIAA0044; MGC23064; PP2A B subunit isoform B56-gamma; PP2A B subunit isoform B'-gamma; PP2A B subunit isoform PR61-gamma; PP2A B subunit isoform R5-gamma; PR61G; protein phosphatase 2, regulatory subunit B (B56), gamma isoform; protein phosphatase 2, regulatory subunit B', gamma isoform; protein phosphatase 2, regulatory subunit B', gamma; Renal carcinoma antigen NY-REN-29; serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform
Molecular Weight
Mass (kDA):
61.061 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 14q32.31 |
| Sequence: | 14; NC_000014.9 (101760573..101927992) |
Tissue Specificity
Highest levels in heart, skeletal muscle and brain. Lower levels in pancreas, kidney, lung and placenta. Very low levels in liver.
Subcellular Localizations
Nucleus. Chromosome, centromere.
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Transformation, Neoplastic
- Carcinoma
- Leukemia
- Metaplastic Cell Transformation
- Malignant Neoplasm Of Lung
- Lung Neoplasms
- Malignant Paraganglionic Neoplasm
- Malnutrition
- Melanoma
- Malignant Neoplasm Of Breast
Interacting Proteins
- CHEK2
- IER3
- MDM2
- PPP2CA
- PPP2R1A
- PPP2R1B
- RAF1
- TP53
Pathways
- Cell Proliferation
- Localization
- Cell Cycle
- Cell Growth
- Rna Interference
- Translation
- Cell Death
- S Phase
- Regulation Of Cell Growth
PTMs
- Phosphorylation
- Dephosphorylation
Research Areas
- Breast Cancer
- Cancer
- Cell Cycle and Replication
- Checkpoint signaling
- DNA Double Strand Break Repair
- DNA Repair
- Neuronal Cell Markers
- Neuroscience
- Neurotransmission
- Protein Phosphatase
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PPP2R5C
bosterbio.com/bosterbio-gene-info-cards/PPP2R5C
References
PMID: 8617797 by Tehrani M.A., et al. Identification of a novel protein phosphatase 2A regulatory subunit highly expressed in muscle.
PMID: 8694763 by Zolnierowicz S., et al. The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.