Protein kinase C theta type (PRKCQ)

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase which mediates non- redundant functions in T-cell receptor (TCR) signaling, including T-cells activation, proliferation, differentiation and survival, by mediating activation of multiple transcription factors like NF-kappa-B, JUN, NFATC1 and NFATC2. In TCR-CD3/CD28-co-stimulated T-cells, is necessary for the activation of NF-kappa-B and JUN, which in turn are crucial for IL2 production, and participates in the calcium-dependent NFATC1 and NFATC2 transactivation.

Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11 on several serine residues, causing CARD11 association with lipid rafts and recruitment of the BCL10-MALT1 complex, which then activates IKK complex, resulting in nuclear translocation and activation of NFKB1. In the signaling pathway leading to JUN activation, acts by phosphorylating the mediator STK39/SPAK and may not act through MAP kinases signaling.