PRKX Antibodies

AND PRKX ELISA kits, PRKX Proteins

Many biological assays use antibodies to detect PRKX, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PRKX in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PRKX antibodies...

We validate the specificity of these antibodies to PRKX by testing them on tissues known to express PRKX positively and negatively. Browse below to find the PRKX antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PRKX Infographic by Boster Bio

All PRKX Products

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Anti-PRKX Antibody

1 Q&As

Western blot analysis of the lysates from HepG2 cells using PRKX antibody

Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using PRKX Antibody

Western blot analysis of lysates from MCF-7 cells, using PRKX Antibody

Human, Mouse, Rat

ELISA, IF, IHC, ICC, WB

$335
Cat # A06585-1
100ul

PRKX (NM_005044) Human Recombinant Protein

Coomassie blue staining of purified PRKX protein

$1062
Cat # PROTP51817
20 µg

PRKX (NM_005044) Human Over-expression Lysate

Human

$628
Cat # LS005613
20 µg, 100 µg

PRKX Overview

Facts about cAMP-dependent protein kinase catalytic subunit PRKX.

PRKX 3D structure. Source: alphafold

cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)

Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that might consist of CREB, SMAD6 and PKD1 and has multiple roles in cellular differentiation and epithelial morphogenesis.

Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis.

Gene Information

Human
Gene Name:	PRKX
Uniprot:	P51817
Entrez:	5613

Family

Belongs to:

protein kinase superfamily

Alternative Names

EC 2.7.11; PKX1EC 2.7.11.1; Protein kinase PKX1; protein kinase, X-linked; serine/threonine-protein kinase PRKX

Molecular Weight

Mass (kDA):
40.896 kDA

Genomic Context


Human

Location:	Xp22.33
Sequence:	X; NC_000023.11 (3604340..3713649, complement)

Tissue Specificity

Widely expressed (at protein level). Specifically expressed in blood by macrophages and granulocytes according to PubMed:9860982.

Subcellular Localizations

Cytoplasm. Nucleus. cAMP induces nuclear translocation.

Diseases

Disorders Of Sex Development
Neoplasms
Xx Male
Polycystic Kidney, Autosomal Dominant
Polycystic Kidney Diseases
Kidney Diseases
Infertility
Malignant Neoplasms
Chromosome Breakage
Congenital Abnormality
Gonadal Dysgenesis
Chromosomal Translocation
Xy Female

Steroid Sulfatase Deficiency Disease
Low Grade Prostatic Intraepithelial Neoplasia
Tissue Adhesions
Klinefelter Syndrome
Neoplasm Metastasis
Melanoma
Kidney Neoplasm

Interacting Proteins

GPKOW
HSP90AB1
PRKAR1A
SMAD6

Pathways

Cell Migration
Epithelial Cell Migration
Kidney Development
Localization
Macrophage Differentiation
Gene Conversion
Cell Differentiation
Cell Proliferation
Brain Development
Cell-matrix Adhesion
Sex Determination
Endothelial Cell Proliferation
Sensitization

System Development
Cell Growth
Regulation Of Angiogenesis
Angiogenesis
Pathogenesis
Rna Interference
Meiosis

PTMs

Phosphorylation

Research Areas

Protein Kinase
Wnt Signaling Pathway

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PRKX

References

PMID: 7633447 by Klink A., et al. The human protein kinase gene PKX1 on Xp22.3 displays Xp/Yp homology and is a site of chromosomal instability.

PMID: 9302280 by Schiebel K., et al. Abnormal XY interchange between a novel isolated protein kinase gene, PRKY, and its homologue, PRKX, accounts for one third of all (Y+)XX males and (Y-)XY females.