cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)

Serine/threonine protein kinase regulated by and mediating cAMP signaling in cells. Acts through phosphorylation of downstream targets that might consist of CREB, SMAD6 and PKD1 and has multiple roles in cellular differentiation and epithelial morphogenesis.

Regulates myeloid cell differentiation through SMAD6 phosphorylation. Involved in nephrogenesis by stimulating renal epithelial cell migration and tubulogenesis.