PTPN12 Antibodies

AND PTPN12 ELISA kits, PTPN12 Proteins

Many biological assays use antibodies to detect PTPN12, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPN12 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPN12 antibodies...

We validate the specificity of these antibodies to PTPN12 by testing them on tissues known to express PTPN12 positively and negatively. Browse below to find the PTPN12 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for PTPN12? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the PTPN12 Western Blot Guide

PTPN12 Infographic by Boster Bio

All PTPN12 Products

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Applications

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Anti-PTPN12 Antibody Picoband®

Western blot analysis of PTPN12 using anti-PTPN12 antibody (A02762-1)

Flow Cytometry analysis of K562 cells using anti-PTPN12 antibody (A02762-1)

Human

ELISA, Flow Cytometry, WB

$370
Cat # A02762-1
100 μg/vial

PTPN12 (NM_002835) Human Over-expression Lysate

Human

$628
Cat # LS005782
20 µg, 100 µg

PTPN12 Overview

Facts about Tyrosine-protein phosphatase non-receptor type 12.

PTPN12 3D structure. Source: alphafold

Tyrosine-protein phosphatase non-receptor type 12 (PTPN12)

Dephosphorylates a range of proteins, and thereby modulates cellular signaling cascades (PubMed:18559503). Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2 (PubMed:17329398, PubMed:27134172).

Selectively dephosphorylates ERBB2 phosphorylated in'Tyr-1112','Tyr-1196', and/or'Tyr-1248' (PubMed:27134172). .

Gene Information

Human
Gene Name:	PTPN12
Uniprot:	Q05209
Entrez:	5782

Family

Belongs to:

protein-tyrosine phosphatase family

Alternative Names

protein tyrosine phosphatase, non-receptor type 12; Protein-tyrosine phosphatase G1; PTPG1tyrosine-protein phosphatase non-receptor type 12; PTP-PESTEC 3.1.3.48

Molecular Weight

Mass (kDA):
88.106 kDA

Genomic Context


Human

Location:	7q11.23
Sequence:	7; NC_000007.14 (77537190..77640069)

Subcellular Localizations

Cytoplasm. Cell junction, focal adhesion. Cell projection, podosome. Partial translocation to focal adhesion sites may be mediated by interaction with SORBS2.

Diseases

Tissue Adhesions
Posttransfusion Purpura
Malignant Neoplasms
Neoplasms
Neoplasm Metastasis
Malignant Neoplasm Of Breast
Autoimmunity
Neoplasm Invasiveness
Cell Transformation, Neoplastic
Carcinoma
Mammary Neoplasms
Cell Invasion
Malignant Squamous Cell Neoplasm

Vascular Diseases
Esophageal Neoplasms
Graves Disease
Protrusion
Hyperinsulinism
Prostatic Neoplasms
Lymphomatoid Papulosis

Interacting Proteins

BCAR1
EGFR
ERBB2
PDGFRB
PSTPIP1

SHC1
TEK

Pathways

Cell Migration
Cell Motility
Cell Adhesion
Localization
Cell Activation
Hyperphosphorylation
T Cell Activation
Lymphocyte Activation
Cytokinesis
Cell Development
Cell Differentiation
Cell Proliferation
Endothelial Cell Migration

Cell Death
Pathogenesis
Protein Phosphorylation
Regulation Of Localization
Regulation Of Focal Adhesion Assembly
Regulation Of Signaling
Proteolysis

PTMs

Phosphorylation
Dephosphorylation

Cleavage
Reduction

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPN12

References

PMID: 1472029 by Takekawa M., et al. Cloning and characterization of a human cDNA encoding a novel putative cytoplasmic protein-tyrosine-phosphatase.

PMID: 8454633 by Yang Q., et al. Cloning and expression of PTP-PEST. A novel, human, nontransmembrane protein tyrosine phosphatase.