Receptor-type tyrosine-protein phosphatase beta (PTPRB)

Plays an essential role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is vital for their maintenance and remodeling.

Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells.