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- Table of Contents
Facts about Receptor-type tyrosine-protein phosphatase beta.
Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells.
Human | |
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Gene Name: | PTPRB |
Uniprot: | P23467 |
Entrez: | 5787 |
Belongs to: |
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protein-tyrosine phosphatase family |
DKFZp686E2262; DKFZp686H15164; EC 3.1.3.48; FLJ44133; HPTPB; HPTP-BETA; MGC142023; MGC59935; protein tyrosine phosphatase, receptor type, B; protein tyrosine phosphatase, receptor type, beta polypeptide; Protein-tyrosine phosphatase beta; PTPB; receptor-type tyrosine-protein phosphatase beta; R-PTP-BETA; Vascular endothelial protein tyrosine phosphatase; VEPTP; VE-PTP
Mass (kDA):
224.301 kDA
Human | |
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Location: | 12q15 |
Sequence: | 12; NC_000012.12 (70515870..70637440, complement) |
Membrane; Single-pass type I membrane protein.
PMID: 2170109 by Krueger N.X., et al. Structural diversity and evolution of human receptor-like protein tyrosine phosphatases.
PMID: 19116766 by Yacyshyn O.K., et al. Tyrosine phosphatase beta regulates angiopoietin-Tie2 signaling in human endothelial cells.