PTPRK Antibodies

AND PTPRK ELISA kits, PTPRK Proteins

Many biological assays use antibodies to detect PTPRK, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with PTPRK in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop PTPRK antibodies...

We validate the specificity of these antibodies to PTPRK by testing them on tissues known to express PTPRK positively and negatively. Browse below to find the PTPRK antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PTPRK Infographic by Boster Bio

All PTPRK Products

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Anti-PTPRK Antibody

Human, Mouse

ELISA, WB

$380
Cat # A05486
100ul

PTPRK Overview

Facts about Receptor-type tyrosine-protein phosphatase kappa.

PTPRK 3D structure. Source: alphafold

Receptor-type tyrosine-protein phosphatase kappa (PTPRK)

Regulation of procedures involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway.

Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin might be a substrate for the catalytic action of PTPRK/PTP-kappa.

Gene Information

Human
Gene Name:	PTPRK
Uniprot:	Q15262
Entrez:	5796

Family

Belongs to:

protein-tyrosine phosphatase family

Alternative Names

DKFZp686C2268; DKFZp779N1045; EC 3.1.3.48; protein tyrosine phosphatase kappa, protein tyrosine phosphatase kappa; protein tyrosine phosphatase, receptor type, K; Protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase, receptor type, kappa; PTPK; receptor type, K (R-PTP-KAPPA; receptor-type tyrosine-protein phosphatase kappa

Molecular Weight

Mass (kDA):
162.102 kDA

Genomic Context


Human

Location:	6q22.33
Sequence:	6; NC_000006.12 (127968785..128520603, complement)

Tissue Specificity

High levels in lung, brain and colon; less in liver, pancreas, stomach, kidney, placenta and mammary carcinoma.

Subcellular Localizations

Cell junction, adherens junction. Cell membrane; Single-pass type I membrane protein.

Diseases

Neoplasms
Tissue Adhesions
Malignant Neoplasms
Posttransfusion Purpura
Lymphoma
Nervousness
Melanoma
Immunologic Deficiency Syndromes
Mammary Neoplasms
Neoplasm Metastasis
Central Nervous System Neoplasms
Liver Carcinoma
Diffuse Large B-cell Lymphoma

Lymphoma, Non-hodgkin
B-cell Lymphomas
Adenoma
Intraepithelial Neoplasia
Metastatic Malignant Neoplasm To The Lymph Node
Malignant Neoplasm Of Breast
Malignant Tumor Of Colon

Interacting Proteins

ERBB2
LOX
TEK

Pathways

Cell Adhesion
Pathogenesis
Cell Migration
Homophilic Cell Adhesion
Cell Proliferation
Glycosylation
Keratinocyte Proliferation
Rna Interference
Hyperphosphorylation
Regulation Of Signal Transduction
Aging
Immune Response
Histone Modification

Nuclear Export
Cell Maturation
Cell Motility
Cell Cycle
Interphase
Contact Inhibition
Cell-cell Adhesion

PTMs

Phosphorylation
Cleavage

Dephosphorylation
Glycosylation

Methylation

Research Areas

Protein Phosphatase

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PTPRK

References

PMID: 8663237 by Fuchs M., et al. Association of human protein-tyrosine phosphatase kappa with members of the armadillo family.

PMID: 9047348 by Yang Y., et al. Molecular cloning and chromosomal localization of a human gene homologous to the murine R-PTP-kappa, a receptor-type protein tyrosine phosphatase.