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- Table of Contents
Facts about Pyrroline-5-carboxylate reductase 2.
Can use both NAD and NADP. Has higher affinity for NADP, but higher catalytic efficiency with NADH (PubMed:2722838, PubMed:6894153).
| Human | |
|---|---|
| Gene Name: | PYCR2 |
| Uniprot: | Q96C36 |
| Entrez: | 29920 |

| Belongs to: |
|---|
| pyrroline-5-carboxylate reductase family |

EC 1.5.1.2; FLJ54750; P5C reductase 2; P5CR 2; P5CR2; pyrroline 5-carboxylate reductase isoform; pyrroline-5-carboxylate reductase 2; pyrroline-5-carboxylate reductase family, member 2
Mass (kDA):
33.637 kDA

| Human | |
|---|---|
| Location: | 1q42.12 |
| Sequence: | 1; NC_000001.11 (225919877..225924340, complement) |
Detected in erythrocytes (at protein level) (PubMed:2722838, PubMed:6894153). Expressed in fetal brain (PubMed:25865492).
Cytoplasm. Mitochondrion.





PMID: 6894153 by Yeh G.C., et al. Pyrroline-5-carboxylate reductase in human erythrocytes.
PMID: 2722838 by Merrill M.J., et al. Purified human erythrocyte pyrroline-5-carboxylate reductase. Preferential oxidation of NADPH.