Pygopus homolog 1 Antibodies

AND PYGO1 ELISA kits, Pygopus homolog 1 Proteins

Many biological assays use antibodies to detect Pygopus homolog 1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Pygopus homolog 1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Pygopus homolog 1 antibodies...

We validate the specificity of these antibodies to Pygopus homolog 1 by testing them on tissues known to express PYGO1 positively and negatively. Browse below to find the PYGO1 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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PYGO1 Infographic by Boster Bio

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PYGO1 (NM_015617) Human Over-expression Lysate

Human

$960
Cat # LS026108
20 µg, 100 µg

PYGO1 Overview

Facts about Pygopus homolog 1.

PYGO1 3D structure. Source: alphafold

Pygopus homolog 1 (PYGO1)

Involved in signal transduction through the Wnt pathway. .

Gene Information

Human
Gene Name:	PYGO1
Uniprot:	Q9Y3Y4
Entrez:	26108

Family

Belongs to:

No superfamily

Alternative Names

DKFZp547G0910; Pygo1; pygopus 1; pygopus homolog 1 (Drosophila); pygopus homolog 1; Pygopus1; Pygopus-1; pygopus-like protein 1

Molecular Weight

Mass (kDA):
45.116 kDA

Genomic Context


Human

Location:	15q21.3
Sequence:	15; NC_000015.10 (55538884..55588971, complement)

Subcellular Localizations

Nucleus.

Diseases

Malignant Neoplasms
Malignant Paraganglionic Neoplasm
Neoplasms
Colorectal Neoplasms
Cell Transformation, Neoplastic
Adenoma
Colonic Neoplasms
Malignant Tumor Of Colon
Colorectal Cancer
Congenital Absence
Rectal Carcinoma
Leukemogenesis
Exencephaly

Tumor Progression
Cleft Palate
Intestinal Neoplasms
Adenoma, Villous
Carcinogenesis
Growth Retardation
Adenomatous Polyposis Coli

Interacting Proteins

BCL9

Pathways

Methylation
Cell Death
Stem Cell Maintenance
Neurogenesis
Kidney Development

PTMs

Methylation

Phosphorylation

Ubiquitination

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PYGO1

References

PMID: 11955446 by Kramps T., et al. Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex.

PMID: 17113272 by Hoffmans R., et al. BCL9-2 binds Arm/beta-catenin in a Tyr142-independent manner and requires Pygopus for its function in Wg/Wnt signaling.