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Prefoldin subunit 5 Antibodies
AND PFDN5 ELISA kits, Prefoldin subunit 5 Proteins
Many biological assays use antibodies to detect Prefoldin subunit 5, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Prefoldin subunit 5 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Prefoldin subunit 5 antibodies...
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PFDN5 Infographic by Boster Bio
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PFDN5 Overview
Facts about Prefoldin subunit 5.
Prefoldin subunit 5 (PFDN5)
Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.
Represses the transcriptional activity of MYC. .
Gene Information
| Human | |
|---|---|
| Gene Name: | PFDN5 |
| Uniprot: | Q99471 |
| Entrez: | 5204 |
Family
| Belongs to: |
|---|
| prefoldin subunit alpha family |
Alternative Names
c-myc binding protein; C-Myc-binding protein Mm-1; MM-1; MM1MGC71907; Myc modulator 1; myc modulator-1; PFD5MGC5329; prefoldin 5; prefoldin subunit 5
Molecular Weight
Mass (kDA):
17.328 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.13 |
| Sequence: | 12; NC_000012.12 (53295451..53299450) |
Tissue Specificity
Highly expressed in pancreas and skeletal muscle and moderately in other tissues.
Subcellular Localizations
[Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Nucleus.
Diseases
- Neoplasms
- Lymphoma
- Leukemia
- Malignant Neoplasms
- Cytogenetic Abnormality
- Cell Transformation, Neoplastic
- Autoimmunity
- Adenoma
- Tongue Neoplasms
- Malignant Neoplasm Of Tongue
- Neoplasms, Experimental
- Infertility
Interacting Proteins
- CALCOCO2
- GLRX3
- IKZF3
- LINC01600
- PFDN2
- PSME3
- VBP1
Pathways
- Cell Proliferation
- Cell Cycle
- Protein Folding
- Cell Adhesion
- Cellular Process
- Hypersensitivity
- Establishment Of Protein Localization
- Localization
- Cell Death
- Regulation Of Cell Proliferation
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/PFDN5
bosterbio.com/bosterbio-gene-info-cards/PFDN5
References
PMID: 9792694 by Mori K., et al. MM-1, a novel c-Myc-associating protein that represses transcriptional activity of c-Myc.
PMID: 11567024 by Fujioka Y., et al. MM-1, a c-Myc-binding protein, is a candidate for a tumor suppressor in leukemia/lymphoma and tongue cancer.