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- Table of Contents
POT1 Antibodies
AND POT1 ELISA kits, POT1 Proteins
Many biological assays use antibodies to detect POT1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with POT1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop POT1 antibodies...
Designing a Western blot for POT1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the POT1 Western Blot GuidePOT1 Infographic by Boster Bio
All POT1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, WB
$370
Cat # A00696-2
100 μg/vial
Cat # A00696-2
100 μg/vial
POT1 Overview
Facts about Protection of telomeres protein 1.
Protection of telomeres protein 1 (POT1)
Component of the telomerase ribonucleoprotein (RNP) complex that is critical for the replication of chromosome termini. Is a part of this double-stranded telomeric DNA- binding TRF1 complex which is involved in the regulation of telomere length by cis-inhibition of telomerase.
Also functions as a single-stranded telomeric DNA-binding protein and so may function as a downstream effector of the TRF1 complex and might transduce information about telomere maintenance and/or span to the telomere terminus. Component of the shelterin complex (telosome) which is involved in the regulation of telomere length and protection.
Gene Information
| Human | |
|---|---|
| Gene Name: | POT1 |
| Uniprot: | Q9NUX5 |
| Entrez: | 25913 |
Family
| Belongs to: |
|---|
| telombin family |
Alternative Names
DKFZp586D211; HPOT1; POT1 protection of telomeres 1 homolog; POT1; POT1-like telomere end-binding protein; protection of telomeres 1 homolog (S. pombe); protection of telomeres protein 1
Molecular Weight
Mass (kDA):
71.442 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 7q31.33 |
| Sequence: | 7; NC_000007.14 (124822386..124929983, complement) |
Tissue Specificity
Ubiquitous.
Subcellular Localizations
Nucleus. Chromosome, telomere. Colocalizes with telomeric DNA.
Diseases
- Malignant Neoplasms
- Neoplasms
- Genomic Instability
- Telomere Shortening
- Cell Transformation, Neoplastic
- Cytogenetic Abnormality
- Carcinoma
- Malignant Paraganglionic Neoplasm
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Werner Syndrome
- Malignant Neoplasm Of Stomach
Interacting Proteins
- ACD
- ALDH3A1
- ANXA2
- CCDC32
- CLIC3
- CNST
- DOK2
- GFPT2
- GPA33
- HAAO
Pathways
- Telomere Maintenance
- Senescence
- Cell Cycle
- Telomere Binding
- Dna Repair
- Dna Replication
- Telomere Capping
- Localization
- Aging
- Pathogenesis
- Rna Interference
- S Phase
- Cell Division
PTMs
- Phosphorylation
Research Areas
- Cancer
- Cell Cycle and Replication
- Chromatin Research
- DNA replication, Transcription, Translation and Splicing
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/POT1
bosterbio.com/bosterbio-gene-info-cards/POT1
References
PMID: 11349150 by Baumann P., et al. Pot1, the putative telomere end-binding protein in fission yeast and humans.
PMID: 12391173 by Baumann P., et al. Human Pot1 (protection of telomeres) protein: cytolocalization, gene structure, and alternative splicing.