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RAB21 Antibodies
AND RAB21 ELISA kits, RAB21 Proteins
Many biological assays use antibodies to detect RAB21, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RAB21 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RAB21 antibodies...
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RAB21 Infographic by Boster Bio
All RAB21 Products
Product
Figures
Specificity
Applications
Price
Dog, Human, Monkey, Mouse, Rat
IF, IHC, WB
$523
Cat # M05683-1
100 µl
Cat # M05683-1
100 µl
Dog, Human, Monkey, Mouse, Rat
IF, IHC, WB
$523
Cat # M05683-2
100 µl
Cat # M05683-2
100 µl
RAB21 Overview
Facts about Ras-related protein Rab-21.
Ras-related protein Rab-21 (RAB21)
Regulates integrin internalization and recycling, but doesn't influence the traffic of endosomally translocated receptors generally (By similarity). As a result, may regulate cell adhesion and migration (By similarity).
During the mitosis of adherent cells, controls the endosomal trafficking of integrins that's required for the successful completion of cytokinesis (PubMed:18804435). Involved in neurite growth (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | RAB21 |
| Uniprot: | Q9UL25 |
| Entrez: | 23011 |
Family
| Belongs to: |
|---|
| small GTPase superfamily |
Alternative Names
KIAA0118ras-related protein Rab-21; RAB21, member RAS oncogene family
Molecular Weight
Mass (kDA):
24.348 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q21.1 |
| Sequence: | 12; NC_000012.12 (71754863..71800286) |
Tissue Specificity
Widely expressed. In jejunal tissue, predominantly expressed in the apical region of the epithelial cell layer of the villi, weak expression, if any, in the crypt epithelium. Capillary endothelium and some cell types in the lamina propria also show expression.
Subcellular Localizations
Endoplasmic reticulum membrane; Lipid-anchor. Golgi apparatus, trans-Golgi network. Golgi apparatus membrane. Early endosome membrane. Cytoplasmic vesicle membrane. Cleavage furrow. Cell projection, neuron projection. Colocalizes with ANKRD27 and VAMP7 in neurites (By similarity). In nonpolarized epithelial Caco-2 cells, found in the endoplasmic reticulum; in polarized cells, observed in vesicles in the apical cytoplasm (PubMed:10887961). During mitosis, in mid-telophase, localized in the ingressing cleavage furrow (PubMed:18804435). In late telophase, detected at the opposite poles of the dau
Diseases
- Malignant Neoplasms
- Neoplasms
- Cell Invasion
- Tissue Adhesions
- Neoplasm Invasiveness
- Cell Transformation, Neoplastic
- Adult Acute Lymphocytic Leukemia
- Malnutrition
- Tetanus
- Tumor Progression
- Dehydration
- Aneuploidy
- Carcinoma
Interacting Proteins
- APPL1
Pathways
- Transport
- Localization
- Endocytosis
- Cytokinesis
- Cell Migration
- Cell Adhesion
- Cell Motility
- Secretory Pathway
- Seed Maturation
- Hypersensitivity
- Endocytic Recycling
- Membrane Fusion
- Membrane Budding
PTMs
- Phosphorylation
Research Areas
- Signal Transduction
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RAB21
bosterbio.com/bosterbio-gene-info-cards/RAB21
References
PMID: 10887961 by Opdam F.J.M., et al. Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells.
PMID: 15561770 by Simpson J.C., et al. A role for the small GTPase Rab21 in the early endocytic pathway.