RANGRF Antibodies

AND RANGRF ELISA kits, RANGRF Proteins

Many biological assays use antibodies to detect RANGRF, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RANGRF in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RANGRF antibodies...

We validate the specificity of these antibodies to RANGRF by testing them on tissues known to express RANGRF positively and negatively. Browse below to find the RANGRF antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RANGRF Infographic by Boster Bio

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MOG1 (RANGRF) (NM_016492) Human Recombinant Protein

Coomassie blue staining of purified RANGRF protein

$1249
Cat # PROTQ9HD47
20 µg

RANGRF Overview

Facts about Ran guanine nucleotide release factor.

RANGRF 3D structure. Source: alphafold

Ran guanine nucleotide release factor (RANGRF)

May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603).

Regulates the levels of GTP-bound RAN from the nucleus, and thus plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A in the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:23420830, PubMed:21621375).

Gene Information

Human
Gene Name:	RANGRF
Uniprot:	Q9HD47
Entrez:	29098

Family

Belongs to:

MOG1 family

Alternative Names

HSPC165; HSPC236; MOG1 homolog; MOG1DKFZp686F02139; RAN guanine nucleotide release factor; Ran-binding protein MOG1; RanGNRF; RANGNRFMGC110973

Molecular Weight

Mass (kDA):
20.448 kDA

Genomic Context


Human

Location:	17p13.1
Sequence:	17; NC_000017.11 (8288670..8290087)

Tissue Specificity

Isoform 1 and isoform 2 are ubiquitously expressed (PubMed:11290418). Detected in heart and brain (PubMed:21621375).

Subcellular Localizations

Nucleus. Cytoplasm, perinuclear region. Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. May shuttle between the nucleus and cytoplasm.

Diseases

Brugada Syndrome (disorder)
Cardiac Arrhythmia
Atrial Fibrillation
Cardiac Fibrillation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RANGRF

References

PMID: 11290418 by Marfatia K.A., et al. Identification and characterization of the human MOG1 gene.

PMID: 18184654 by Wu L., et al. Identification of a new co-factor, MOG1, required for the full function of cardiac sodium channel Nav1.5.