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- Table of Contents
Facts about Rap guanine nucleotide exchange factor 6.
.
Human | |
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Gene Name: | RAPGEF6 |
Uniprot: | Q8TEU7 |
Entrez: | 51735 |
Belongs to: |
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No superfamily |
DKFZp667N084; DKFZp686I15116; KIA001LB; PDZ domain-containing guanine nucleotide exchange factor 2; PDZ domain-containing guanine nucleotide exchange factor I; PDZ-GEF2RA-GEF-2PDZGEF2PDZ domain containing guanine nucleotide exchange factor (GEF) 2; RAGEF2; Rap guanine nucleotide exchange factor (GEF) 6; rap guanine nucleotide exchange factor 6
Mass (kDA):
179.423 kDA
Human | |
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Location: | 5q31.1 |
Sequence: | 5; NC_000005.10 (131423921..131635229, complement) |
Cytoplasm. Cell membrane. Upon binding to M-Ras, it translocates to the plasma membrane.
PMID: 12581858 by Kuiperij H.B., et al. Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.
PMID: 11524421 by Gao X., et al. Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M- Ras.