Putative RNA-binding protein 15B (RBM15B)

RNA-binding protein that acts as a key regulator of N6- methyladenosine (m6A) methylation of RNAs, thereby regulating different processes, such as alternative splicing of mRNAs and X chromosome inactivation mediated by Xist RNA (PubMed:16129689, PubMed:27602518). Associated component of the WMM complex, a complex that mediates N6-methyladenosine (m6A) methylation of RNAs, a modification that plays a role in the efficiency of mRNA splicing and RNA processing (PubMed:27602518).

Plays a crucial role in m6A methylation, possibly by binding target RNAs and recruitment the WMM complicated (PubMed:27602518). Involved in random X inactivation mediated by Xist RNA: acts by binding Xist RNA and recruitment the WMM complex, which mediates m6A methylation, resulting in target YTHDC1 reader on Xist RNA and promoting transcription repression activity of Xist (PubMed:27602518).