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- Table of Contents
Facts about Retinol dehydrogenase 16.
Oxidoreductase with a Taste for NAD.
Oxidizes all- trans-retinol and 13-cis-retinol into the corresponding aldehydes.Has higher activity towards CRBP-bound retinol than with free retinol. Oxidizes 3-alpha-hydroxysteroids.
| Human | |
|---|---|
| Gene Name: | RDH16 |
| Uniprot: | O75452 |
| Entrez: | 8608 |

| Belongs to: |
|---|
| short-chain dehydrogenases/reductases (SDR) family |

EC 1.1; EC 1.1.1; EC 1.1.1.105; Microsomal NAD+-dependent retinol dehydrogenase 4; retinol dehydrogenase 16 (all-trans and 13-cis); retinol dehydrogenase 16 (all-trans); retinol dehydrogenase 16; RODH4; RODH-4; SDR9C8; short chain dehydrogenase/reductase family 9C, member 8; Sterol/retinol dehydrogenase
Mass (kDA):
35.673 kDA

| Human | |
|---|---|
| Location: | 12q13.3 |
| Sequence: | 12; NC_000012.12 (56951431..56959374, complement) |
Highly expressed in adult liver (at protein level). Detected in endometrium, liver and foreskin. Detected in the spineous layers of adult skin, and at lower levels in basal and granular skin layers. Detected in fetal liver and lung.
Microsome membrane. Endoplasmic reticulum membrane; Single-pass membrane protein.


PMID: 9677409 by Gough W.H., et al. cDNA cloning and characterization of a new human microsomal NAD+- dependent dehydrogenase that oxidizes all-trans-retinol and 3alpha- hydroxysteroids.
PMID: 10329026 by Jurukovski V., et al. Cloning and characterization of retinol dehydrogenase transcripts expressed in human epidermal keratinocytes.