Beta-1,3-N-acetylglucosaminyltransferase radical fringe (RFNG)

Glycosyltransferase that initiates the elongation of O- linked fucose residues attached to EGF-like repeats in the extracellular domain of Notch molecules. Modulates NOTCH1 activity by changing O-fucose residues at specific EGF-like domains leading to enhancement of NOTCH1 activation by DLL1 and JAG1.

May be involved in limb formation and in neurogenesis. .