RNF139 Antibodies

AND RNF139 ELISA kits, RNF139 Proteins

Many biological assays use antibodies to detect RNF139, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RNF139 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RNF139 antibodies...

We validate the specificity of these antibodies to RNF139 by testing them on tissues known to express RNF139 positively and negatively. Browse below to find the RNF139 antibody that suites your experiment. We have 2 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RNF139 Infographic by Boster Bio

All RNF139 Products

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Price

RNF139 (NM_007218) Human Over-expression Lysate

Human

$628
Cat # LS011236
20 µg, 100 µg

Anti-RNF139 Antibody

Human

ELISA, WB

$370
Cat # A06257-2
100 μl/vial

RNF139 Overview

Facts about E3 ubiquitin-protein ligase RNF139.

RNF139 3D structure. Source: alphafold

E3 ubiquitin-protein ligase RNF139 (RNF139)

E3-ubiquitin ligase; acts as a negative regulator of the cell proliferation through mechanisms between G2/M arrest and cell death. Required for MHC class I ubiquitination in cells expressing the cytomegalovirus protein US2 before dislocation from the endoplasmic reticulum (ER).

Affects SREBP processing by hindering the SREBP/SCAP complex translocation from the ER to the Golgi, thereby reducing SREBF2 target gene expression. Required for INSIG1 ubiquitination.

Gene Information

Human
Gene Name:	RNF139
Uniprot:	Q8WU17
Entrez:	11236

Family

Belongs to:

No superfamily

Alternative Names

EC 6.3.2.-; HRCA1; patched related protein translocated in renal cancer; RCA1multiple membrane spanning receptor TRC8; ring finger protein 139MGC31961; Translocation in renal carcinoma on chromosome 8 protein; TRC8E3 ubiquitin-protein ligase RNF139

Molecular Weight

Mass (kDA):
75.994 kDA

Genomic Context


Human

Location:	8q24.13
Sequence:	8; NC_000008.11 (124474880..124488618)

Tissue Specificity

Highly expressed in testis, placenta and adrenal gland. Moderate expression in heart, brain, liver, skeletal muscle and pancreas, and low expression in lung and kidney.

Subcellular Localizations

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Diseases

Carcinoma
Renal Cell Carcinoma
Malignant Neoplasms
Malignant Neoplasm Of Kidney
Kidney Neoplasm
Von Hippel-lindau Syndrome
Neoplasms
Chromosomal Translocation
Basal Cell Carcinoma
Dysgerminoma
Tumor Angiogenesis
Pyotraumatic Dermatitis

Cytomegalovirus Infections
(balanced Rearrangements Or Structural Markers Nec) Or (balanced Translocations)
Ovarian Neoplasm
Familial Renal Cell Carcinoma
Glioblastoma
Malignant Paraganglionic Neoplasm
Haploinsufficiency