E3 ubiquitin-protein ligase RNF19A (RNF19A)

E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes UBE2L3 and UBE2L6 in the form of a thioester and then directly transfers the ubiquitin to targeted substrates, such as SNCAIP or CASR. Especially ubiquitinates pathogenic SOD1 variants, which contributes to their proteasomal degradation and to neuronal protection.

.