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- Table of Contents
Facts about E3 ubiquitin-protein ligase RNF19A.
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Human | |
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Gene Name: | RNF19A |
Uniprot: | Q9NV58 |
Entrez: | 25897 |
Belongs to: |
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RBR family |
DKFZp566B1346; dorfin; Double ring-finger protein; E3 ubiquitin-protein ligase RNF19A; EC 6.3.2; EC 6.3.2.-; p38; protein p38 interacting with transcription factor Sp1; RING finger protein 19 isoform; ring finger protein 19; ring finger protein 19Ap38 protein; ring-IBR-ring domain containing protein Dorfin; RNF19
Mass (kDA):
90.696 kDA
Human | |
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Location: | 8q22.2 |
Sequence: | 8; NC_000008.11 (100257059..100336204, complement) |
Widely expressed, with highest levels in heart. Ubiquitously expressed in the central nervous system.
Membrane; Multi-pass membrane protein. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Present in the hyaline inclusion bodies specifically found in motor neurons from amyotrophic lateral sclerosis patients. Present in the Lewy bodies specifically found in neurons from Parkinson disease patients.
PMID: 11237715 by Niwa J., et al. A novel centrosomal ring-finger protein, dorfin, mediates ubiquitin ligase activity.
PMID: 10976766 by Gunther M., et al. A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening.