mRNA-capping enzyme Antibodies

AND RNGTT ELISA kits, mRNA-capping enzyme Proteins

Many biological assays use antibodies to detect mRNA-capping enzyme, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with mRNA-capping enzyme in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop mRNA-capping enzyme antibodies...

We validate the specificity of these antibodies to mRNA-capping enzyme by testing them on tissues known to express RNGTT positively and negatively. Browse below to find the RNGTT antibody that suites your experiment. We have 4 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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RNGTT Infographic by Boster Bio

All RNGTT Products

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Product

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Specificity

Applications

Price

Anti-mRNA-capping enzyme RNGTT Antibody

Human, Mouse, Rat

IF, WB

$405
Cat # A09317
100ul

HCE (RNGTT) (NM_003800) Human Recombinant Protein

$813
Cat # PROTO60942
20 µg

HCE (RNGTT) (NM_003800) Human Over-expression Lysate

Human

$628
Cat # LS008732
100 µg

Anti-RNGTT Antibody Picoband®

Human

ELISA, Flow Cytometry, IF, IHC, ICC, WB

$370
Cat # A09317-1
100 µg/vial

RNGTT Overview

Facts about mRNA-capping enzyme.

RNGTT 3D structure. Source: alphafold

mRNA-capping enzyme (RNGTT)

Bifunctional mRNA-capping enzyme exhibiting RNA 5'- triphosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two measures of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by shifting the gmp moiety of GTP to the 5'-diphosphate terminus.

Gene Information

Human
Gene Name:	RNGTT
Uniprot:	O60942
Entrez:	8732

Family

Belongs to:

No superfamily

Alternative Names

CAP1AmRNA-capping enzyme; hCAP; HCE1DKFZp686J2031; HCEHCAP1; RNA guanylyltransferase and 5'-phosphatase

Molecular Weight

Mass (kDA):
68.557 kDA

Genomic Context


Human

Location:	6q15
Sequence:	6; NC_000006.12 (88609897..88963618, complement)

Tissue Specificity

Isoform 1 and isoform 4 (at a lesser extent) are expressed in cerebrum, cerebellum, thyroid, lung, heart, liver, kidney, spleen, large intestine, testis, skin and muscle.

Subcellular Localizations

Nucleus.

Diseases

Carcinoma, Transitional Cell
Cell Transformation, Neoplastic
Malignant Neoplasms
Neoplasms
Malignant Neoplasm Of Urinary Bladder
Carcinoma

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RNGTT

References

PMID: 9371772 by Yue Z., et al. Mammalian capping enzyme complements mutant Saccharomyces cerevisiae lacking mRNA guanylyltransferase and selectively binds the elongating form of RNA polymerase II.

PMID: 9512541 by Yamada-Okabe T., et al. Isolation and characterization of a human cDNA for mRNA 5'-capping enzyme.