Replication protein A 30 kDa subunit (RPA4)

As part of the alternative replication protein A complex, aRPA, binds single-stranded DNA and probably plays a role in DNA repair. When compared with the RPA2-containing, canonical RPA complex, may not support chromosomal DNA replication and cell cycle progression through S-phase.

The aRPA may not promote efficient priming by DNA polymerase alpha but could encourage DNA polymerase delta synthesis in the presence of PCNA and replication factor C (RFC), the double incision/excision response of nucleotide excision repair and RAD51-dependent strand exchange. .