Regulatory-associated protein of mTOR (RPTOR)

Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity that regulates cell growth and survival, and autophagy in response to hormonal and nutrient signals; functions as a scaffold for recruitment mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids.

Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which contributes to the activation of this RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling into mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complicated and the Rag GTPases.