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- Table of Contents
RTF1 Antibodies
AND RTF1 ELISA kits, RTF1 Proteins
Many biological assays use antibodies to detect RTF1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RTF1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RTF1 antibodies...
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RTF1 Infographic by Boster Bio
All RTF1 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey
ELISA, Flow Cytometry, IHC, WB
$370
Cat # A05784-1
100 µg/vial
Cat # A05784-1
100 µg/vial
RTF1 Overview
Facts about RNA polymerase-associated protein RTF1 homolog.
RNA polymerase-associated protein RTF1 homolog (RTF1)
Component of the PAF1 complex (PAF1C) which has multiple functions during transcription by RNA polymerase II and is implicated in regulation of development and maintenance of embryonic stem cell pluripotency. PAF1C associates with RNA polymerase II through discussion with POLR2A CTD non- phosphorylated and'Ser-2'- and'Ser-5'-phosphorylated forms and is involved in transcriptional elongation, acting both indepentently and synergistically with TCEA1 and in cooperation with the DSIF complex and HTATSF1.
PAF1C is required for transcription of Hox and Wnt target genes. PAF1C is involved in hematopoiesis and stimulates transcriptional activity of KMT2A/MLL1; it promotes leukemogenesis through association with KMT2A/MLL1-rearranged oncoproteins, such as KMT2A/MLL1-MLLT3/AF9 and KMT2A/MLL1-MLLT1/ENL.
Gene Information
| Human | |
|---|---|
| Gene Name: | RTF1 |
| Uniprot: | Q92541 |
| Entrez: | 23168 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
KIAA0252GTL7; ortholog of mouse gene trap locus 7; RNA polymerase-associated protein RTF1 homolog; Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Molecular Weight
Mass (kDA):
80.313 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 15q15.1 |
| Sequence: | 15; NC_000015.10 (41417104..41483563) |
Subcellular Localizations
Nucleus, nucleoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Congenital Abnormality
- Radiation Injury
- Disease Of Capillaries
- Infectious Mononucleosis
- Microscopic Polyangiitis
- Colonic Neoplasms
- Necrotizing Glomerulonephritis
- Plant Tumors
- Carcinoma
- Carcinogenesis
- Diabetic Microangiopathy
Interacting Proteins
- CDC73
- PAF1
Pathways
- Methylation
- Histone Modification
- Histone Methylation
- Chromatin Remodeling
- Localization
- Filamentous Growth
- Rna Interference
- Histone Ubiquitination
- Chromosome Segregation
- Teliospore Formation
- Cell Division
- Translation
- Cell Cycle
PTMs
- Methylation
- Phosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RTF1
bosterbio.com/bosterbio-gene-info-cards/RTF1
References
PMID: 19345177 by Ding L., et al. A genome-scale RNAi screen for Oct4 modulators defines a role of the Paf1 complex for embryonic stem cell identity.
PMID: 20178742 by Kim J., et al. The human PAF1 complex acts in chromatin transcription elongation both independently and cooperatively with SII/TFIIS.