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In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels because of stimulation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by creation of heterotetramers with RYR3.
|ryanodine receptor (TC 1.A.3.1) family|
|Sequence:||1; NC_000001.11 (237042184..237833988)|
Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta.
Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Sarcoplasmic reticulum. The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic.