Ryanodine receptor 2 (RYR2)

Calcium channel that mediates the release of Ca(2+) in the sarcoplasmic reticulum to the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia.

In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels because of stimulation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by creation of heterotetramers with RYR3.