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Ryanodine receptor 2 Antibodies
AND RYR2 ELISA kits, Ryanodine receptor 2 Proteins
Many biological assays use antibodies to detect Ryanodine receptor 2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Ryanodine receptor 2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Ryanodine receptor 2 antibodies...
Designing a Western blot for Ryanodine receptor 2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RYR2 Western Blot GuideRYR2 Infographic by Boster Bio
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RYR2 Overview
Facts about Ryanodine receptor 2.
Ryanodine receptor 2 (RYR2)
Calcium channel that mediates the release of Ca(2+) in the sarcoplasmic reticulum to the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia.
In cardiac myocytes, calcium release is triggered by increased Ca(2+) levels because of stimulation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by creation of heterotetramers with RYR3.
Gene Information
| Human | |
|---|---|
| Gene Name: | RYR2 |
| Uniprot: | Q92736 |
| Entrez: | 6262 |
Family
| Belongs to: |
|---|
| ryanodine receptor (TC 1.A.3.1) family |
Alternative Names
ARVC2arrhythmogenic right ventricular dysplasia 2; ARVD2; Cardiac muscle-type ryanodine receptor; hRYR-2; ryanodine receptor 2 (cardiac); ryanodine receptor 2; RyR2; RYR-2; VTSIPCardiac muscle ryanodine receptor-calcium release channel
Molecular Weight
Mass (kDA):
564.567 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 1q43 |
| Sequence: | 1; NC_000001.11 (237042184..237833988) |
Tissue Specificity
Detected in heart muscle (at protein level). Heart muscle, brain (cerebellum and hippocampus) and placenta.
Subcellular Localizations
Sarcoplasmic reticulum membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein. Sarcoplasmic reticulum. The number of predicted transmembrane domains varies between orthologs, but both N-terminus and C-terminus seem to be cytoplasmic.
Diseases
- Tachycardia, Ventricular
- Cardiac Arrhythmia
- Polymorphic Ventricular Tachycardia
- Ventricular Tachycardia, Catecholaminergic Polymorphic, 1 (disorder)
- Sudden Cardiac Death
- Sudden Death
- Cardiomyopathies
- Syncope
- Cardiac Death
- Heart Diseases
- Malignant Paraganglionic Neoplasm
- Arrhythmogenic Right Ventricular Dysplasia
- Long Qt Syndrome
Interacting Proteins
- FKBP1A
- FKBP1B
- MDM2
Pathways
- Transport
- Cell Death
- Aging
- Localization
- Pathogenesis
- Hibernation
- Hyperphosphorylation
- Programmed Cell Death
- Electron Transport
- Electron Transport Chain
- Immune Response
- Proteolysis
- Muscle Contraction
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RYR2
bosterbio.com/bosterbio-gene-info-cards/RYR2
References
PMID: 8809036 by Tunwell R.E.A., et al. The human cardiac muscle ryanodine receptor-calcium release channel: identification, primary structure and topological analysis.
PMID: 11159936 by Tiso N., et al. Identification of mutations in the cardiac ryanodine receptor gene in families affected with arrhythmogenic right ventricular cardiomyopathy type 2 (ARVD2).