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Rif1 Antibodies
AND Rif1 ELISA kits, Rif1 Proteins
Many biological assays use antibodies to detect Rif1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Rif1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Rif1 antibodies...
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Rif1 Overview
Facts about Telomere-associated protein RIF1.
Telomere-associated protein RIF1 (Rif1)
Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: functions by promoting non-homologous end joining (NHEJ)- mediated repair of DSBs (PubMed:23333305, PubMed:23306437, PubMed:23306439). In response to DNA damage, interacts with ATM- phosphorylated TP53BP1 (PubMed:23333305, PubMed:23306437, PubMed:23306439).
Interaction with TP53BP1 contributes to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs (By similarity). Once recruited to DSBs, RIF1 and TP53BP1 act by boosting NHEJ-mediated repair of DSBs (PubMed:23333305, PubMed:23306437).
Gene Information
| Mouse | |
|---|---|
| Gene Name: | Rif1 |
| Uniprot: | Q6PR54 |
| Entrez: | 51869 |
Family
| Belongs to: |
|---|
| RIF1 family |
Alternative Names
DKFZp434D1026; DKFZp781N1478; FLJ10599; FLJ12870; RAP1 interacting factor homolog (yeast); Rap1-interacting factor 1 homolog; telomere-associated protein RIF1
Molecular Weight
Mass (kDA):
266.228 kDA
Genomic Context
| Mouse | |
|---|---|
| Location: | 2 C1.1|2 29.98 cM |
| Sequence: | 2; |
Tissue Specificity
Expressed in Sertoli cells, prospermatagonia, early primary spermatocytes, and in oocytes at all stages of their growth. Expressed in embryonic stem (ES) and embryonic germ (EG) cells: expression is lost upon differentiation.
Diseases
- Neoplasms
- Neoplasms, Experimental
- Hypoxia
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Sarcoma, Experimental
- Fibrosarcoma
- Carcinoma
- Mammary Neoplasms
- Sarcoma
Pathways
- Dna Replication
- Cell Cycle
- Localization
- Cell Killing
- Telomere Maintenance
- Mating
- Dna Replication Checkpoint
- Cell Growth
- Rna Interference
- Interphase
- Dna Repair
- S Phase
- Pathogenesis
PTMs
- Nitration
- Acetylation
- Phosphorylation
- Farnesylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Rif1
bosterbio.com/bosterbio-gene-info-cards/Rif1
References
PMID: 15042697 by Adams I.R., et al. Identification and characterisation of mRif1: a mouse telomere- associated protein highly expressed in germ cells and embryo-derived pluripotent stem cells.
PMID: 23333305 by Chapman J.R., et al. RIF1 is essential for 53BP1-dependent nonhomologous end joining and suppression of DNA double-strand break resection.