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- Table of Contents
RPN2 Antibodies
AND RPN2 ELISA kits, RPN2 Proteins
Many biological assays use antibodies to detect RPN2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with RPN2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop RPN2 antibodies...
Designing a Western blot for RPN2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the RPN2 Western Blot GuideRPN2 Infographic by Boster Bio
All RPN2 Products
Product
Figures
Specificity
Applications
Price
Human
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A05006-1
100 µg/vial
Cat # A05006-1
100 µg/vial
RPN2 Overview
Facts about Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2.
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (RPN2)
Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X- Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER).
All subunits are required for a maximal enzyme activity. .
Gene Information
| Human | |
|---|---|
| Gene Name: | RPN2 |
| Uniprot: | P04844 |
| Entrez: | 6185 |
Family
| Belongs to: |
|---|
| SWP1 family |
Alternative Names
RIBIIREC 2.4.1.119; ribophorin IIDolichyl-diphosphooligosaccharide--protein glycosyltransferase 63 kDa subunit; ribophorin-2; RPNII; RPN-IIdolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2; SWP1
Molecular Weight
Mass (kDA):
69.284 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 20q11.23 |
| Sequence: | 20; NC_000020.11 (37179046..37241623) |
Tissue Specificity
Expressed in all tissues tested.
Subcellular Localizations
Endoplasmic reticulum. Endoplasmic reticulum membrane; Multi-pass membrane protein.
Diseases
- Neoplasms
- Malignant Neoplasms
- Malignant Neoplasm Of Breast
- Carcinoma
- Myeloid Leukemia
- Mammary Neoplasms
- Leukemia
- Myeloid Neoplasm
- Neoplasm Metastasis
- Parkinson Disease
- Carcinogenesis
- Cell Transformation, Neoplastic
Pathways
- Proteolysis
- Localization
- Drug Resistance
- Glycosylation
- Dna Repair
- Cell Cycle
- Transport
- Induction Of Apoptosis
- Parturition
- Spindle Pole Body Duplication
- Protein Unfolding
- Spermatogenesis
- Double-strand Break Repair
PTMs
- Glycosylation
- Cleavage
- Ubiquitination
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/RPN2
bosterbio.com/bosterbio-gene-info-cards/RPN2
References
PMID: 3034581 by Crimaudo C., et al. Human ribophorins I and II: the primary structure and membrane topology of two highly conserved rough endoplasmic reticulum-specific glycoproteins.
PMID: 25135935 by Cherepanova N.A., et al. Oxidoreductase activity is necessary for N-glycosylation of cysteine- proximal acceptor sites in glycoproteins.