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- Table of Contents
Facts about Store-operated calcium entry-associated regulatory factor.
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Human | |
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Gene Name: | SARAF |
Uniprot: | Q96BY9 |
Entrez: | 51669 |
Belongs to: |
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SARAF family |
Store-operated calcium entry-associated regulatory factor
Mass (kDA):
36.975 kDA
Human | |
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Location: | 8p12 |
Sequence: | 8; NC_000008.11 (30063003..30083208, complement) |
Highly expressed in macrophages.
Endoplasmic reticulum membrane; Single-pass type I membrane protein. Translocates to the endoplasmic reticulum-plasma membrane (ER-PM) region in a STIM1-dependent manner following cytosolic Ca(2+) elevation.; [Isoform 2]: Endoplasmic reticulum membrane; Single-pass type I membrane protein.
PMID: 22464749 by Palty R., et al. SARAF inactivates the store operated calcium entry machinery to prevent excess calcium refilling.
PMID: 30481768 by Albarran L., et al. EFHB is a Novel Cytosolic Ca2+ Sensor That Modulates STIM1-SARAF Interaction.