Store-operated calcium entry-associated regulatory factor (SARAF)

Negative regulator of store-operated Ca(2+) entry (SOCE) involved in protecting cells from Ca(2+) overfilling. In response to cytosolic Ca(2+) elevation after endoplasmic reticulum Ca(2+) refilling, promotes a slow inactivation of STIM (STIM1 or STIM2)- reliant SOCE action: possibly act by facilitating the deoligomerization of STIM to effectively turn off ORAI when the endoplasmic reticulum lumen is filled with the appropriate Ca(2+) levels, and thus preventing the overload of the mobile with excessive Ca(2+) ions.

.