This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Facts about Protein strawberry notch homolog 2.
Plays a role in bone homeostasis; required as a positive regulator in TNFSF11//RANKL-mediated osteoclast fusion via a DCSTAMP- dependent pathway. Might also be required in the regulation of osteoblast differentiation (By similarity).
Human | |
---|---|
Gene Name: | SBNO2 |
Uniprot: | Q9Y2G9 |
Entrez: | 22904 |
Belongs to: |
---|
SBNO family |
KIAA0963; SBNO2 strawberry notch homolog 2 (Drosophila); SNO; STNO
Mass (kDA):
150.275 kDA
Human | |
---|---|
Location: | 19p13.3 |
Sequence: | 19; NC_000019.10 (1107637..1174268, complement) |
Detected in macrophages. IL10 regulates expression in a STAT3-dependent way.
PMID: 18025162 by El Kasmi K.C., et al. A transcriptional repressor and corepressor induced by the STAT3- regulated anti-inflammatory signaling pathway.
PMID: 25903009 by Grill M., et al. Strawberry notch homolog 2 is a novel inflammatory response factor predominantly but not exclusively expressed by astrocytes in the central nervous system.