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SCN8A Antibodies
AND SCN8A ELISA kits, SCN8A Proteins
Many biological assays use antibodies to detect SCN8A, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SCN8A in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SCN8A antibodies...
Designing a Western blot for SCN8A? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SCN8A Western Blot GuideSCN8A Infographic by Boster Bio
All SCN8A Products
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SCN8A Overview
Facts about Sodium channel protein type 8 subunit alpha.
Sodium channel protein type 8 subunit alpha (SCN8A)
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.
In macrophages and melanoma cells, isoform 5 may participate in the control of podosome and invadopodia formation. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SCN8A |
| Uniprot: | Q9UQD0 |
| Entrez: | 6334 |
Family
| Belongs to: |
|---|
| sodium channel (TC 1.A.1.10) family |
Alternative Names
CerIII; hNa6/Scn8a voltage-gated sodium channel; MED; NaCh6; Nav1.6; PN4; sodium channel protein type 8 subunit alpha; Sodium channel protein type VIII subunit alpha; sodium channel, voltage gated, type VIII, alpha polypeptide; sodium channel, voltage gated, type VIII, alpha subunit; Voltage-gated sodium channel subunit alpha Nav1.6
Molecular Weight
Mass (kDA):
225.28 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 12q13.13 |
| Sequence: | 12; NC_000012.12 (51591233..51812864) |
Tissue Specificity
Isoform 5 is expressed in non-neuronal tissues, such as monocytes/macrophages.
Subcellular Localizations
Cell membrane; Multi-pass membrane protein. Cell projection, axon. Mainly localizes to the axon initial segment.; [Isoform 5]: Cytoplasmic vesicle. Some vesicles are localized adjacent to melanoma invadopodia and macrophage podosomes. Does not localize to the plasma membrane.
Diseases
- Nervousness
- Ataxia
- Epilepsy
- Nervous System Disorder
- Sclerosis
- Pain
- Multiple Sclerosis
- Dystonia Disorders
- Movement Disorders
- Demyelination
- Weakness
- Cell Invasion
Pathways
- Localization
- Myelination
- Pathogenesis
- Transport
- Membrane Depolarization
- Muscle Atrophy
- Innervation
- Phagocytosis
- Cognition
- Cell Proliferation
- Synaptic Transmission
- Endocytosis
- Neuroprotection
PTMs
- Phosphorylation
- Biotinylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SCN8A
bosterbio.com/bosterbio-gene-info-cards/SCN8A
References
PMID: 9295353 by Plummer N.W., et al. Alternative splicing of the sodium channel SCN8A predicts a truncated two-domain protein in fetal brain and non-neuronal cells.
PMID: 9828131 by Plummer N.W., et al. Exon organization, coding sequence, physical mapping, and polymorphic intragenic markers for the human neuronal sodium channel gene SCN8A.