This website uses cookies to ensure you get the best experience on our website.
- Table of Contents
Sestrin-1 Antibodies
AND SESN1 ELISA kits, Sestrin-1 Proteins
Many biological assays use antibodies to detect Sestrin-1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sestrin-1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sestrin-1 antibodies...
Designing a Western blot for Sestrin-1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SESN1 Western Blot GuideSESN1 Infographic by Boster Bio
All SESN1 Products
Product
Figures
Specificity
Applications
Price
Human, Mouse, Rat
ELISA, Flow Cytometry, IF, ICC, WB
$370
Cat # A05559-2
100 µg/vial
Cat # A05559-2
100 µg/vial
Human, Mouse, Rat
Flow Cytometry, WB
$370
Cat # M05559
100 μl/vial
Cat # M05559
100 μl/vial
SESN1 Overview
Facts about Sestrin-1.
Sestrin-1 (SESN1)
Functions as an intracellular leucine sensor that negatively regulates the TORC1 signaling pathway throughout the GATOR complex. In absence of leucine, binds the GATOR subcomplex GATOR2 and prevents TORC1 signaling.
Binding of leucine to SESN2 disrupts its interaction with GATOR2 thereby activating the TORC1 signaling pathway (PubMed:25263562, PubMed:26449471). This stress-inducible metabolic regulator may also play a role in protection against oxidative and genotoxic stresses (By similarity).
Gene Information
| Human | |
|---|---|
| Gene Name: | SESN1 |
| Uniprot: | Q9Y6P5 |
| Entrez: | 27244 |
Family
| Belongs to: |
|---|
| sestrin family |
Alternative Names
MGC138241; MGC142129; p53-regulated protein PA26; PA26p53 activated gene 26; SEST1p53 regulated PA26 nuclear protein; sestrin 1; sestrin-1
Molecular Weight
Mass (kDA):
56.557 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 6q21 |
| Sequence: | 6; NC_000006.12 (108984309..109094846, complement) |
Tissue Specificity
Widely expressed.
Subcellular Localizations
Nucleus. Cytoplasm.
Diseases
- Malignant Neoplasms
- Neoplasms
- Instabilities, Chromosomal
- Exposure To Ionizing Radiation
- Situs Ambiguus
- Genotoxic Stress
- Growth Arrest
- Radiation Injury
- Malnutrition
- Embryonal Carcinoma
- Malignant Neoplasm Of Breast
Pathways
- Cell Cycle
- Aging
- Dna Repair
- Cell Cycle Arrest
- Response To Ionizing Radiation
- Rna Interference
- Transport
- Gene Silencing
- Cellular Senescence
- Hypersensitivity
- Regulation Of Gene Expression
- Inflammatory Response
PTMs
- Phosphorylation
Research Areas
- Cell Cycle and Replication
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SESN1
bosterbio.com/bosterbio-gene-info-cards/SESN1
References
PMID: 9926927 by Velasco-Miguel S., et al. PA26, a novel target of the p53 tumor suppressor and member of the GADD family of DNA damage and growth arrest inducible genes.
PMID: 12607115 by Peeters H., et al. PA26 is a candidate gene for heterotaxia in humans: identification of a novel PA26-related gene family in human and mouse.