Sh3bp1 Antibodies

AND Sh3bp1 ELISA kits, Sh3bp1 Proteins

Many biological assays use antibodies to detect Sh3bp1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with Sh3bp1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop Sh3bp1 antibodies...

We validate the specificity of these antibodies to Sh3bp1 by testing them on tissues known to express Sh3bp1 positively and negatively. Browse below to find the Sh3bp1 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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Sh3bp1 Infographic by Boster Bio

All Sh3bp1 Products

Filter by Application:

Product

Figures

Specificity

Applications

Price

Anti-3BP1 SH3BP1 Antibody

Human, Mouse

ELISA, WB

$380
Cat # A11321
100ul

Anti-SH3BP1 Mouse Monoclonal Antibody [Clone ID: OTI1C9]

+11

Human, Mouse

IHC, WB

$523
Cat # M11321
100 µl

SH3BP1 (NM_018957) Human Over-expression Lysate

Human

$960
Cat # LS023616
100 µg

Sh3bp1 Overview

Facts about SH3 domain-binding protein 1.

SH3 domain-binding protein 1 (Sh3bp1)

GTPase activating protein (GAP) which specifically converts GTP-bound Rho-type GTPases including RAC1 and CDC42 in their inactive GDP-bound form (PubMed:7621827). By specifically inactivating RAC1 in the leading edge of migrating cells, it modulates the spatiotemporal organization of cell protrusions that's essential for proper cell migration.

Additionally negatively modulates CDC42 in the process of actin remodeling and the creation of epithelial cell junctions. Through its GAP activity toward RAC1 and/or CDC42 plays a particular role in phagocytosis of large particles.

Gene Information

Mouse
Gene Name:	Sh3bp1
Uniprot:	P55194
Entrez:	20401

Family

Belongs to:

No superfamily

Alternative Names

3BP-1; ARHGAP43; SH3 domain binding protein 1; SH3 domain-binding protein 1; SH3-domain binding protein 1

Molecular Weight

Mass (kDA):
74.172 kDA

Genomic Context


Mouse

Location:	15\|15 E1
Sequence:	15;

Tissue Specificity

Expressed in all tissues examined. Highest levels found in spleen and brain, lowest in heart and liver.

Diseases

Tissue Adhesions

Pathways

Epithelial Cell-cell Adhesion
Cell Migration
Cell Motility
Locomotion
Stress Fiber Assembly
Cell-cell Adhesion

PTMs

Phosphoprotein

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/Sh3bp1

References

PMID: 7621827 by Cicchetti P., et al. 3BP-1, an SH3 domain binding protein, has GAP activity for Rac and inhibits growth factor-induced membrane ruffling in fibroblasts.

PMID: 1379745 by Cicchetti P., et al. Identification of a protein that binds to the SH3 region of Abl and is similar to Bcr and GAP-rho.