SHANK2 Antibodies

AND SHANK2 ELISA kits, SHANK2 Proteins

Many biological assays use antibodies to detect SHANK2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SHANK2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SHANK2 antibodies...

We validate the specificity of these antibodies to SHANK2 by testing them on tissues known to express SHANK2 positively and negatively. Browse below to find the SHANK2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SHANK2 Infographic by Boster Bio

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Anti-Shank 2 Antibody

6 Q&As

Human

$399
Cat # A03782
100μl

SHANK2 Overview

Facts about SH3 and multiple ankyrin repeat domains protein 2.

SHANK2 3D structure. Source: alphafold

SH3 and multiple ankyrin repeat domains protein 2 (SHANK2)

Seems like an adapter protein in the postsynaptic density (PSD) of excitatory synapses that interconnects receptors of the postsynaptic membrane including NMDA-type and metabotropic glutamate receptors, and the actin-based cytoskeleton. May play a role in the structural and functional organization of the dendritic spine and synaptic junction.

Gene Information

Human
Gene Name:	SHANK2
Uniprot:	Q9UPX8
Entrez:	22941

Family

Belongs to:

SHANK family

Alternative Names

AUTS17; cortactin binding protein 1; cortactin SH3 domain-binding protein; Cortactin-binding protein 1; CORTBP1; CORTBP1CTTNBP1; CTTNBP1; GKAP/SAPAP interacting protein; KIAA1022; proline-rich synapse associated protein 1; Proline-rich synapse-associated protein 1; ProSAP1; SH3 and multiple ankyrin repeat domains 2; SH3 and multiple ankyrin repeat domains protein 2; SHANK; SHANK2; SPANK-3

Molecular Weight

Mass (kDA):
158.822 kDA

Genomic Context


Human

Location:	11q13.3-q13.4
Sequence:	11; NC_000011.10 (70467854..71252724, complement)

Tissue Specificity

Isoform 3 is present in epithelial colonic cells (at protein level).

Subcellular Localizations

Apical cell membrane. Cytoplasm. Cell junction, synapse. Cell junction, synapse, postsynaptic density. Cell projection, growth cone. Cell projection, dendritic spine. Colocalizes with cortactin in growth cones in differentiating hippocampal neurons. Colocalized with PDE4D to the apical membrane of colonic crypt cells (By similarity).

Diseases

Autistic Disorder
Autism Spectrum Disorders
Neoplasms
Carcinoma
Child Development Disorders, Pervasive
Nervousness
Malignant Squamous Cell Neoplasm
Neoplasm Metastasis
Malignant Neoplasms
Tissue Adhesions
Fibrosis
Diarrhea

Secretory Diarrhea
Cystic Fibrosis
Schizophrenia
Nervous System Disorder
Malnutrition
Metastatic Malignant Neoplasm To The Lymph Node
Mouth Neoplasms

Interacting Proteins

CRK
GRB2
NCK1
PIK3R1
PLCG1

Pathways

Localization
Transport
Cell Adhesion
Synaptic Transmission
Pathogenesis
Ion Transport
Rna Interference
Brain Development
Endocytosis
Synapse Maturation
Protein Phosphorylation
Macromolecular Complex Assembly
Hyperphosphorylation

Cell Migration
Myelination
Anaphase
System Development
Translation
Arp2/3 Complex-mediated Actin Nucleation
Water Transport

PTMs

Phosphorylation

Methylation

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SHANK2

References

PMID: 16293618 by Han W., et al. Shank2 associates with and regulates Na+/H+ exchanger 3.

PMID: 10506216 by Lim S., et al. Characterization of the shank family of synaptic proteins. Multiple genes, alternative splicing, and differential expression in brain and development.