SHC2 Antibodies

AND SHC2 ELISA kits, SHC2 Proteins

Many biological assays use antibodies to detect SHC2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SHC2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SHC2 antibodies...

We validate the specificity of these antibodies to SHC2 by testing them on tissues known to express SHC2 positively and negatively. Browse below to find the SHC2 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SHC2 Infographic by Boster Bio

All SHC2 Products

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Anti-SHC2/Sck Antibody

1 Q&As

Immunohistochemical analysis of paraffin-embedded human tonsil

Western blot analysis of lysates from Jurkat cells, using SHC2 Antibody

Human, Rat

IHC, WB

$335
Cat # A09660
100ul

SHC2 Overview

Facts about SHC-transforming protein 2.

SHC2 3D structure. Source: alphafold

SHC-transforming protein 2 (SHC2)

Signaling adapter that couples activated growth factor receptors to signaling pathway in neurons. Involved in the signal transduction pathways of neurotrophin-activated Trk receptors in cortical neurons (By similarity).

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Gene Information

Human
Gene Name:	SHC2
Uniprot:	P98077
Entrez:	25759

Family

Belongs to:

No superfamily

Alternative Names

neuronal Shc adaptor homolog; Protein Sck; SCKSH2 domain protein C2; SHC (Src homology 2 domain containing) transforming protein 2; SHCBSHC-transforming protein B; SHC-transforming protein 2; SLI; Src homology 2 domain-containing-transforming protein C2

Molecular Weight

Mass (kDA):
61.916 kDA

Genomic Context


Human

Location:	19p13.3
Sequence:	19; NC_000019.10 (416583..461011, complement)

Tissue Specificity

Expressed in brain. Expressed at high level in the hypothalamus and at low level in the caudate nucleus.

Diseases

Nervousness
Neuroblastoma
Nerve Damage
Specific Language Impairment
Language Disorders
Pediatric Neoplasm
Language Development Disorders
Atrophy
Tumor Angiogenesis
Diseases In Twins
Hypertrophy

Neoplasms
Multiple System Atrophy
Impaired Cognition
Gait Disorders, Neurologic
Tissue Damage
Hypoglossal Nerve Injuries

Interacting Proteins

EGFR
ERBB2
KIT
MET

Pathways

Regeneration
Senescence
Membrane Depolarization
Cell Development
Aging
Angiogenesis
Pathogenesis

Localization

PTMs

Phosphorylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SHC2

References

PMID: 9507002 by Nakamura T., et al. N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling.

PMID: 8760305 by Pelicci G., et al. A family of Shc related proteins with conserved PTB, CH1 and SH2 regions.