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- Table of Contents
SKAP1 Antibodies
AND SKAP1 ELISA kits, SKAP1 Proteins
Many biological assays use antibodies to detect SKAP1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SKAP1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SKAP1 antibodies...
Designing a Western blot for SKAP1? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.
Open the SKAP1 Western Blot GuideSKAP1 Infographic by Boster Bio
All SKAP1 Products
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SKAP1 Overview
Facts about Src kinase-associated phosphoprotein 1.
Src kinase-associated phosphoprotein 1 (SKAP1)
Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway. Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells.
May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. .
Gene Information
| Human | |
|---|---|
| Gene Name: | SKAP1 |
| Uniprot: | Q86WV1 |
| Entrez: | 8631 |
Family
| Belongs to: |
|---|
| SKAP family |
Alternative Names
SCAP1; SCAP1pp55; SKAP1; SKAP55; SKAP55SKAP-55; src family associated phosphoprotein 1; Src family-associated phosphoprotein 1; src kinase associated phosphoprotein 1; src kinase-associated phosphoprotein 1; Src kinase-associated phosphoprotein of 55 kDa
Molecular Weight
Mass (kDA):
41.432 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.32 |
| Sequence: | 17; NC_000017.11 (48133438..48430250, complement) |
Tissue Specificity
Highly expressed in thymocytes and peripheral blood lymphocytes. Also expressed in spleen cells and testis. Present in T-cells (at protein level).
Subcellular Localizations
Cytoplasm. Nucleus. Cell membrane. Upon T-cell stimulation, translocates to lipid rafts at the cell membrane.
Diseases
- Tissue Adhesions
- Malignant Neoplasms
- Lymphoma
- Neoplasms
- T-cell Lymphoma
- Leukemia
- Autoimmunity
- Neoplasm Metastasis
- Extravasation
- Melanoma
- Lymphoma, T-cell, Cutaneous
- Monocytic Leukemia
- Malignant Neoplasm Of Ovary
Interacting Proteins
- BLCAP
- FAM102A
- FYB1
- PRAM1
- SH2D4A
Pathways
- Conjugation
- Cell Activation
- T Cell Activation
- Cytokine Production
- Cell Motility
- Lymphocyte Activation
- Cell Adhesion
- Cell Proliferation
- Localization
- Integrin Activation
- Hyperphosphorylation
- Regulation Of Signaling
- Mitosis
PTMs
- Phosphorylation
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SKAP1
bosterbio.com/bosterbio-gene-info-cards/SKAP1
References
PMID: 9195899 by Marie-Cardine A., et al. Molecular cloning of SKAP55, a novel protein that associates with p59fyn in human T-lymphocytes.
PMID: 9748251 by Marie-Cardine A., et al. Molecular interaction between the Fyn-associated protein SKAP55 and the SLP-76-associated phosphoprotein SLAP-130.