SLC6A3 Antibodies

AND SLC6A3 ELISA kits, SLC6A3 Proteins

Many biological assays use antibodies to detect SLC6A3, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SLC6A3 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SLC6A3 antibodies...

We validate the specificity of these antibodies to SLC6A3 by testing them on tissues known to express SLC6A3 positively and negatively. Browse below to find the SLC6A3 antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for SLC6A3? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the SLC6A3 Western Blot Guide

SLC6A3 Infographic by Boster Bio

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Anti-Dopamine Transporter/SLC6A3 Antibody Picoband®

Western blot analysis of Dopamine Transporter/SLC6A3 using anti-Dopamine Transporter/SLC6A3 antibody (A00369-3)

Flow Cytometry analysis of THP-1 cells using anti-Dopamine Transporter/SLC6A3 antibody (A00369-3)

Human

ELISA, Flow Cytometry, WB

$370
Cat # A00369-3
100 μg/vial

SLC6A3 Overview

Facts about Sodium-dependent dopamine transporter.

SLC6A3 3D structure. Source: alphafold

Sodium-dependent dopamine transporter (SLC6A3)

Amine transporter. Terminates the action of dopamine by its high affinity sodium-dependent reuptake into presynaptic terminals.

Gene Information

Human
Gene Name:	SLC6A3
Uniprot:	Q01959
Entrez:	6531

Family

Belongs to:

sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family

Alternative Names

DA transporter; DAT1; DATDAT1Solute carrier family 6 member 3; SLC6A3; sodium-dependent dopamine transporter; solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; VNTR

Molecular Weight

Mass (kDA):
68.495 kDA

Genomic Context


Human

Location:	5p15.33
Sequence:	5; NC_000005.10 (1392794..1445440, complement)

Tissue Specificity

Highly expressed in substantia nigra.

Subcellular Localizations

Cell membrane; Multi-pass membrane protein.

Diseases

Attention Deficit Hyperactivity Disorder
Variable Number Tandem Repeat
Parkinson Disease
Malnutrition
Schizophrenia
Mental Disorders
Depressive Disorder
Secondary Parkinson Disease
Dysequilibrium Syndrome
Bipolar Disorder
Neurotoxicity Syndromes

Substance-related Disorders
Nervousness
Anxiety Disorders
Inattention
Nerve Degeneration

Interacting Proteins

DRD2
GPR37
Pick1
RIT2
Rit2

SNCA

Pathways

Transport
Dopamine Uptake
Pathogenesis
Localization
Dopamine Transport
Sensitization
Cell Death
Locomotion
Innervation
Response To Methylphenidate
Aging
Cognition
Synaptic Transmission

Endocytosis
Glycosylation
Proteolysis
Translation
Neuroprotection
Habituation
Serotonin Uptake

PTMs

Phosphorylation
Biotinylation
Reduction
Glycosylation
Methylation
Dephosphorylation

Cleavage
Oxidation
Demethylation
Hydroxylation
Ubiquitination
Iodination

Deglycosylation

Research Areas

Neuroscience

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SLC6A3

References

PMID: 1359373 by Vandenbergh D.J., et al. A human dopamine transporter cDNA predicts reduced glycosylation, displays a novel repetitive element and provides racially-dimorphic TaqI RFLPs.

PMID: 1406597 by Giros B., et al. Cloning, pharmacological characterization, and chromosome assignment of the human dopamine transporter.