Sodium/hydrogen exchanger 4 (Slc9a4)

Plays an essential role in signal transduction. May play a technical role in the kidney in rectifying cell volume in response to extreme fluctuations of hyperosmolar-stimulated cell shrinkage.

Is comparatively amiloride and ethylisopropylamiloride (EIPA) insensitive. Can be activated under conditions of hyperosmolar-induced cell shrinkage in a sustained intracellular acidification-dependence manner.