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- Table of Contents
SMARCE1 Antibodies
AND SMARCE1 ELISA kits, SMARCE1 Proteins
Many biological assays use antibodies to detect SMARCE1, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMARCE1 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMARCE1 antibodies...
Designing an IHC experiment for SMARCE1? The guide has the expected staining pattern, antigen retrieval and fixation, antibodies backed by real IHC images, the tissue controls to run alongside, and protocols taken from published papers.
Open the SMARCE1 IHC GuideSMARCE1 Infographic by Boster Bio
All SMARCE1 Products
Product
Figures
Specificity
Applications
Price
Human, Monkey, Mouse, Rat
ELISA, Flow Cytometry, IF, IHC, ICC, WB
$370
Cat # A03739-2
100 μg/vial
Cat # A03739-2
100 μg/vial
Human, Mouse, Rat
IP, IF, IHC, ICC, WB
$370
Cat # M03739-1
100 μl/vial
Cat # M03739-1
100 μl/vial
SMARCE1 Overview
Facts about SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1.
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1 (SMARCE1)
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out crucial enzymatic activities, changing chromatin structure by changing DNA-histone contacts within a nucleosome within an ATP-dependent manner.
Belongs to the neural progenitors- specific chromatin remodeling complex (npBAF complicated ) as well as the neuron-specific chromatin remodeling complex (nBAF complicated ). During neural development a switch from a stem/progenitor into a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become dedicated to their adult condition.
Gene Information
| Human | |
|---|---|
| Gene Name: | SMARCE1 |
| Uniprot: | Q969G3 |
| Entrez: | 6605 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
BAF57BRG1-associated factor 57; chromatin remodeling complex BRG1-associated factor 57; subfamily e, member 1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin e1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatinsubfamily E member 1
Molecular Weight
Mass (kDA):
46.649 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 17q21.2 |
| Sequence: | 17; NC_000017.11 (40624962..40647818, complement) |
Subcellular Localizations
Nucleus.
Diseases
- Malignant Neoplasms
- Neoplasms
- Malignant Neoplasm Of Breast
- Mammary Neoplasms
- Carcinoma
- Neurofibromatosis 1
- Adenocarcinoma
- Prostatic Neoplasms
- Ductal Breast Carcinoma
- Malignant Neoplasm Of Prostate
- Cell Transformation, Neoplastic
- Lymphatic Metastasis
- Cholangiocarcinoma
Interacting Proteins
- ARID2
- BRMS1
- CCDC172
- CDR2
- CEP170P1
- CEP63
- CEP70
- DISC1
- EPS8
- EXOC7
Pathways
- Chromatin Remodeling
- Atp-dependent Chromatin Remodeling
- Cell Cycle
- Cell Proliferation
- Cell Differentiation
- Gonad Development
- Sex Differentiation
- Response To Lipopolysaccharide
- Neurogenesis
- Dna Recombination
- Regulation Of Gene Expression
- Mammary Gland Development
- Sex Determination
PTMs
- Acetylation
Research Areas
- Apoptosis
- DNA Repair
- DNA replication, Transcription, Translation and Splicing
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMARCE1
bosterbio.com/bosterbio-gene-info-cards/SMARCE1
References
PMID: 9435219 by Wang W., et al. Architectural DNA binding by a high-mobility-group/kinesin-like subunit in mammalian SWI/SNF-related complexes.
PMID: 12192000 by Battaglioli E., et al. REST repression of neuronal genes requires components of the hSWI.SNF complex.