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SMPDL3B Antibodies

AND SMPDL3B ELISA kits, SMPDL3B Proteins

Many biological assays use antibodies to detect SMPDL3B, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SMPDL3B in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SMPDL3B antibodies...

We validate the specificity of these antibodies to SMPDL3B by testing them on tissues known to express SMPDL3B positively and negatively. Browse below to find the SMPDL3B antibody that suites your experiment. We have 1 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

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SMPDL3B Infographic by Boster Bio

SMPDL3B protein infographic

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SMPDL3B (NM_014474) Human Over-expression Lysate

SMPDL3B Human Over-expression Lysates NM_001009568

SMPDL3B Human Over-expression Lysates NM_001009568

SMPDL3B Human Over-expression Lysates NM_014474

Human

$960
Cat # LS027293
20 µg, 100 µg

SMPDL3B Overview

Facts about Acid sphingomyelinase-like phosphodiesterase 3b.

SMPDL3B 3D structure

SMPDL3B 3D structure. Source: alphafold

Acid sphingomyelinase-like phosphodiesterase 3b (SMPDL3B)

Lipid-modulating phosphodiesterase (PubMed:26095358). Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity.

Acts as a negative regulator of Toll-like receptor signaling (By similarity). .

Gene Information

Human
Gene Name:	SMPDL3B
Uniprot:	Q92485
Entrez:	27293

Gene Information

Family

Belongs to:

acid sphingomyelinase family

Family

Alternative Names

acid sphingomyelinase-like phosphodiesterase 3b; ASML3BASM-like phosphodiesterase 3b; EC 3.1.4.-; sphingomyelin phosphodiesterase, acid-like 3B

Molecular Weight

Mass (kDA):
50.814 kDA

Molecular Weight

Genomic Context


Human

Location:	1p35.3
Sequence:	1; NC_000001.11 (27934955..27959152)

Subcellular Localizations

Secreted. Cell membrane; Lipid-anchor, GPI-anchor.

Subcellular Localization

Diseases

Segmental Glomerulosclerosis
Focal Glomerulosclerosis
Glomerulosclerosis (disorder)
Proteinuria Of Undiagnosed Cause
Kidney Failure, Chronic
Kidney Diseases

Renal Glomerular Disease

Disease

Pathways

Pathogenesis
Glomerular Filtration

Pathways

PTMs

Disulfide bond
Glycoprotein

GPI-anchor
Lipoprotein

Bosterbio | ELISA Kits, Antibodies, Antibody Company

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SMPDL3B

References

PMID: 26095358 by Heinz L.X., et al. The lipid-modifying enzyme SMPDL3B negatively regulates innate immunity.