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- Table of Contents
Facts about Sorting nexin-9.
Plays a role in macropinocytosis. Promotes internalization of TNFR.
Human | |
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Gene Name: | SNX9 |
Uniprot: | Q9Y5X1 |
Entrez: | 51429 |
Belongs to: |
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sorting nexin family |
MST155; MSTP155; Protein SDP1; SDP1; SH3 and PX domain-containing protein 1; SH3PX1WISP; SH3PXD3ASH3 and PX domain-containing protein SH3PX1; sorting nexin 9; sorting nexin-9; WiskSH3 and PX domain-containing protein 3A
Mass (kDA):
66.592 kDA
Human | |
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Location: | 6q25.3 |
Sequence: | 6; NC_000006.12 (157716046..157945077) |
Widely expressed, with highest levels in heart and placenta, and lowest levels in thymus and peripheral blood leukocytes.
Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle, clathrin-coated vesicle. Golgi apparatus, trans-Golgi network. Cell projection, ruffle. Cytoplasm. Localized at sites of endocytosis at the cell membrane. Detected on newly formed macropinosomes. Transiently recruited to clathrin-coated pits at a late stage of clathrin-coated vesicle formation. Colocalizes with the actin cytoskeleton at the cell membrane.
PMID: 11485546 by Teasdale R.D., et al. A large family of endosome-localized proteins related to sorting nexin 1.
PMID: 10531379 by Howard L., et al. Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1.