SOCS2 Antibodies

AND SOCS2 ELISA kits, SOCS2 Proteins

Many biological assays use antibodies to detect SOCS2, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SOCS2 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SOCS2 antibodies...

We validate the specificity of these antibodies to SOCS2 by testing them on tissues known to express SOCS2 positively and negatively. Browse below to find the SOCS2 antibody that suites your experiment. We have 3 of these antibodies and many publications and validation images.

If you cannot find antibodies that fit your needs, contact us for making custom antibodies. We have a full suite of custom antibody services covering from research to diagnostic and therapeutic applications.

Designing a Western blot for SOCS2? The guide has the expected band size, antibodies backed by real blot images, the controls to run alongside, and protocols taken from published papers.

Open the SOCS2 Western Blot Guide

SOCS2 Infographic by Boster Bio

All SOCS2 Products

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Product

Figures

Specificity

Applications

Price

Anti-SOCS2 Antibody Picoband®

Anti-Picoband antibody, PB, Western blottingAll lanes: Anti SOCS2 (PB9400) at 0

Human, Rat

$370
Cat # PB9400
100 μg/vial

Anti-SOCS2 Rabbit Monoclonal Antibody

Western blot analysis of SOCS2 using anti-SOCS2 antibody (M01584-1)

Human

IP, IF, ICC, WB

$370
Cat # M01584-1
100 μl/vial

SOCS2 (NM_003877) Human Over-expression Lysate

Human

$628
Cat # LS008835
20 µg, 100 µg

SOCS2 Overview

Facts about Suppressor of cytokine signaling 2.

SOCS2 3D structure. Source: alphafold

Suppressor of cytokine signaling 2 (SOCS2)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. SOCS2 appears to be a negative regulator in the growth hormone/IGF1 signaling pathway.

Probable substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin- protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. .

Gene Information

Human
Gene Name:	SOCS2
Uniprot:	O14508
Entrez:	8835

Family

Belongs to:

No superfamily

Alternative Names

CIS2; CIS2CIS-2; Cish2; Cytokine-inducible SH2 protein 2; SOCS2; SOCS-2; SOCS-2STAT-induced STAT inhibitor 2; SSI2; SSI-2STAT induced STAT inhibitor-2; SSI2STAT-induced STAT inhibitor-2; STATI2; STATI2suppressor of cytokine signaling-2; suppressor of cytokine signaling 2

Molecular Weight

Mass (kDA):
22.172 kDA

Genomic Context


Human

Location:	12q22
Sequence:	12; NC_000012.12 (93569849..93626236)

Tissue Specificity

High expression in heart, placenta, lung, kidney and prostate.

Diseases

Janiceps
Malignant Neoplasms
Neoplasms
Inflammation
Leukemia
Carcinoma
Malignant Neoplasm Of Breast
Diabetes Mellitus
Mammary Neoplasms
Nervousness
Myeloid Leukemia
Cell Transformation, Neoplastic
Liver Carcinoma

Lymphoma
Insulin Resistance
Obesity
Kidney Diseases
Dwarfism
Hypertrophy
Hyperplasia

Interacting Proteins

CUL5
ELOC
EPOR
KIT

Pathways

Pathogenesis
Cell Proliferation
Cell Differentiation
Secretion
Immune Response
Methylation
Cell Activation
Cell Cycle
Lactation
Regeneration
T Cell Activation
Cell Growth
Aging

Cytokine Production
Regulation Of Growth
Neurogenesis
Cell Death
Gland Development
T Cell Differentiation
Insulin Secretion

PTMs

Phosphorylation
Methylation
Ubiquitination
Dephosphorylation

Demethylation
Reduction
Cleavage
Acetylation

Research Areas

Signal Transduction

For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SOCS2

References

PMID: 9266833 by Minamoto S., et al. Cloning and functional analysis of new members of STAT induced STAT inhibitor (SSI) family: SSI-2 and SSI-3.

PMID: 9344848 by Masuhara M., et al. Cloning and characterization of novel CIS family genes.