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SP140 Antibodies
AND SP140 ELISA kits, SP140 Proteins
Many biological assays use antibodies to detect SP140, such as Western Blot (WB), ELISA, Flow Cytometry, Immunocytochemistry (IHC). These antibodies can be polyclonal or monoclonal, and react with SP140 in Human, Mouse, Rat, and many other animal samples. Boster Bio use mainly mouse and rabbit to develop SP140 antibodies...
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SP140 Overview
Facts about Nuclear body protein SP140.
Nuclear body protein SP140 (SP140)
Component of the body, also known as nuclear domain 10, PML oncogenic domainname, and KR body (PubMed:8910577). May be involved in the pathogenesis of acute promyelocytic leukemia and viral infection (PubMed:8910577).
May play a role in chromatin-mediated regulation of gene expression though it doesn't bind to histone H3 tails (PubMed:24267382). .
Gene Information
| Human | |
|---|---|
| Gene Name: | SP140 |
| Uniprot: | Q13342 |
| Entrez: | 11262 |
Family
| Belongs to: |
|---|
| No superfamily |
Alternative Names
Lymphoid-restricted homolog of Sp100; lymphoid-specific SP100 homolog; LYSP100; LYSP100-A; LYSP100-B; MGC126440; Nuclear autoantigen Sp-140; nuclear body protein SP140; SP140 nuclear body protein; Speckled 140 kDa
Molecular Weight
Mass (kDA):
98.223 kDA
Genomic Context
| Human | |
|---|---|
| Location: | 2q37.1 |
| Sequence: | 2; NC_000002.12 (230202743..230316571) |
Tissue Specificity
High levels in spleen and peripheral blood leukocytes, much lower levels in tonsils, thymus, prostate, ovary, small intestine, and colon (PubMed:8695863, PubMed:8910577.) Very low levels in heart, brain, placenta, lung, liver, skeletal muscle, kidney, and pancreas (PubMed:8910577). Not detected in brain, liver and muscle (PubMed:8695863).
Subcellular Localizations
Nucleus. Nucleus, PML body. Cytoplasm. Localized to nuclear structures termed LANDS, for LYSp100-associated nuclear domains. LANDS are globular, electron-dense structures most often found in the nucleoplasm, but also found at the nuclear membrane and in the cytoplasm, suggesting that these structures may traffic between the cytoplasm and the nucleus (PubMed:8695863). Also colocalizes with PML in a subset of PML nuclear bodies (PubMed:8910577).
Diseases
- Leukemia
- Acute Promyelocytic Leukemia
- Malignant Neoplasms
- Chronic Lymphocytic Leukemia
- Biliary Cirrhosis
- Hematologic Neoplasms
- Salivary Gland Diseases
- Primary Biliary Cirrhosis
- Virus Diseases
- Autoimmune Reaction
- Lymphoid Leukemia
- Liver Cirrhosis
- Carcinoma
Interacting Proteins
- PIN1
Pathways
- Pathogenesis
- Localization
- Methylation
- Mitosis
- Dna Methylation
- Immune Response
- Larval Development
PTMs
For details, visit:
bosterbio.com/bosterbio-gene-info-cards/SP140
bosterbio.com/bosterbio-gene-info-cards/SP140
References
PMID: 8695863 by Dent A.L., et al. LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies.
PMID: 8910577 by Bloch D.B., et al. Identification and characterization of a leukocyte-specific component of the nuclear body.